nigh why this meaning is appearing and what you can do to calculate your savoir vivre on this milieu safer ------------------------- superior paper or Resource -------------------------- JAMA & Archives family JAMA Archives of Dermatology Facial ersatz Surgery forebears drug (1992-2000) encyclopaedic Psychiatry Internal drug Neurology Ophthalmology Otolaryngology-- fount & Neck Surgery Pediatrics & maturing drug Surgery JAMA-franais JAMA "> Authors/Reviewers Readers Institutions/Libraries promise Agents low-down Media calling Seekers/Employers Advertisers ------------------------- VOL.143 NO.12, DECEMBER 2007 ARCHIVES * investigation THIS ARTICLE * * * * * * CITING ARTICLES * * interconnected CONTENT * thesis COLLECTIONS * * * * * * * APARISON OF METHYLPREDNISOLONE extra AZATHIOPRINE OR MYCOPHENOLATE MOFETIL repayment through despite THE TREATMENT OF BULLOUS PEMPHIGOID Stefan Beissert, MD; Thomas Werfel, MD; Uta Frieling, MD; Markus Bhm, MD; Michael Sticherling, MD; Rudolf Stadler, MD; Detlef Zillikens, MD; Berthold Rzany, MD; Nicolas Hunzelmann, MD; Michael Meurer, MD; Harald Gollnick, MD; Thomas Ruzicka, MD; Hans Pillekamp, MD; Volker Junghans, MD; Gisela Bonsmann, MD; Thomas A.Luger, MD _ crafty Dermatol.2007;143(12):1536-1542. dispassionate To sift through the shelter and efficacy of oral methylprednisolonebined with azathioprine sodium or mycophenolate mofetil through despite the treatment of bullous pemphigoid. intention A imminent multicenter, randomized, nonblinded clinical examination topare 2 up groups of patients with bullous pemphigoid undergoing divergent treatments. locale Thirteen departments of dermatology in Germany. PATIENTS Patients with bullous pemphigoid (n = 73) as evidenced by clinical lesions suggestive of bullous pemphigoid, signs of subepidermal blistering on histologic judgement of abrade biopsy specimens, linear deposition of IgG and C3 along the dermoepidermal interchange and deposition of autoantibodies at the blister roof in split- abrade judgement INTERVENTIONS Treatment with methylprednisolone plus azathioprine (azathioprine group) or methylprednisolone plus mycophenolate mofetil (mycophenolate mofetil group). strongest OUE MEASURES The cumulative out-and-out methylprednisolone doses and rates of reprieve unimportant oue measures were shelter profiles and duration of reprieve RESULTS In 38 of 38 patients in the azathioprine gang (100%),plete reprieve was achieved after a bad-tempered SD of 23.18.days vs 42.55. through despite 35 of 35 patients in the mycophenolate mofetil gang (100%).the azathioprine gang the median SD out-and-out cumulative methylprednisolone administer worn was 4967.12 190.mg vs 5754.9692.in the mycophenolate mofetil gang Nine of 38 patients in the azathioprine gang (24%) capable descent 3 or 4 adverse effects vs 6 of 35 patients in the mycophenolate mofetil gang (17%).Azathioprine analysis induced significantly elated liver commission test resultspared with mycophenolate mofetil (_P_ < . Importantly, patients in the azathioprine gang showed significantly higher toxicity grades through despite aspartate aminotransferase (_P_ = .alanine aminotransferase (_P_ = .and _-glutamyltransferase (P_ = .did those in the mycophenolate mofetil gang CONCLUSIONS Mycophenolate mofetil or azathioprine demonstrate efficacy during treatment of bullous pemphigoid, and similar cumulative corticosteroid doses were premised in both treatment arms to oversee manner mycophenolate mofetil showed a significantly drop liver toxicity maximize than azathioprine analysis side REGISTRATION clinicaltrials.Identifier: architect AFFILIATIONS: Departments of Dermatology, University of Mnster, Mnster (Drs Beissert, Frieling, Bhm, Bonsmann, and Luger), Medical teach Hannover, Hannover, (Dr Werfel), University of Kiel, Kiel (Dr Sticherling), University of Erlangen, Erlangen (Dr Sticherling), village health centre Minden, Minden (Dr Stadler), University of Wrzburg, Wrzburg (Dr Zillikens), University of Lbeck, Lbeck (Dr Zillikens), prerogative of Clinical drug Mannheim, University of Heidelberg, Mannheim (Dr Rzany), conflict of evince Based drug Charit- Universittsmedizin, Berlin (Dr Rzany), University of Cologne, Cologne (Dr Hunzelmann), University of Dresden, Dresden (Dr Meurer), University of Magdeburg, Magdeburg (Dr Gollnick), University of Dsseldorf, Dsseldorf (Dr Ruzicka), Ludwig-Maximilians University of Munich, Munich (Dr Ruzicka), University of Ulm, Ulm (Dr Pillekamp), and University of Gttingen, Gttingen (Dr Junghans), Germany.
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