Death of a female addict due to heroin and cocaine overdoses: a case report with multiparameter evaluation

You have forgotten your username or password, we can .My Menu Saved Items дё­ж–‡(з®ЂдЅ") дё­ж–‡(з№Ѓй«") English Deutsch н•њкµ­м–ґ ж—Ґжњ¬иЄћ Franais Espaol Ш§Щ„Ш№Ш±ШЁЩЉШ© Р СѓСЃСЃРєРёР№ Journal Article DEATH OF A FEMALE ADDICT DUE TO HEROIN AND COCAINE OVERDOSES: A CASE REPORT WITH MULTIPARAMETER EVALUATION Journal Publisher Springer Japan ISSN 1860-8965 (Print) 1860-8973 (Online) Category Case Report DOI 10.Collection SpringerLink Date Wednesday, April 30, 2008 CASE REPORT Death of a female addict due to heroin and cocaine overdoses: a case report with multiparameter evaluation Magorzata Kys1 , Sebastian Rojek1, Piotr Kowalski1 and Ewa Rzepecka-Woniak1 (1) Department of Toxicology, Institute of Forensic Medicine, Collegium Medicum, Jagiellonian University, 16 GrzegГіrzecka St.RECEIVED: 7 December 2007 ACCEPTED: 27 February 2008 PUBLISHED ONLINE: 29 April 2008 Abstract This study undertook a multiparameter evaluation of the death of a 21-year-old woman known to be an abuser of heroin and cocaine.Toxicological analysis of multiple postmortem specimens such as blood and hair was carried out using liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS-MS).Blood specimens of the deceased showed the presence of opiumponents such as morphine and its glucuronides together with cocaine and benzoylecgonine.Detected xenobiotic levels probably explained the cause of her death resulting frombined action of unintentional illicit drug overdose.Analysis of four 2-cm long hair segments, a heroin-cocaine addiction for at least 8 months antemortem was able to be documented; the presence of 6-monoacetylmorphine (6-MAM), cocaine, and benzoylecgonine was demonstrated.Histopathological findings of lesions of the internal organs of the deceased were consistent with long heroin and cocaine abuse.Use of multiple parameters, such as blood and hair segments as matrices and drug metabolites such as 6-MAM, morphine, glucuronides, and benzoylecgonine as targetpounds, gave a well-defined outline of her death.Keywords Heroin - Cocaine - Hair analysis - Multiparameter evaluation - LC-APCI-MS-MS - Morphine glucuronides MAGORZATA KYS EMAIL: References secured to subscribers.Find Query Builder Close Clear Within all content Within this journal Export this article Export this article as RIS Text В© Springer.
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