2, WHITNEY B.3, ALBERT LAI 1, TIMOTHY F.4 1 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Henry E.Brain Cancer Research Program, Los Angeles, CA, USA 2 Department of Neurology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA 3 Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA 4 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Jonssonprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Henry E.Brain Cancer Research Program, Los Angeles, CA, USA To whom correspondence should be addressed..ABSTRACT Bevacizumab inbination with chemotherapy is now being studied for the treatment of malignant gliomas.The risk of intracranial hemorrhage has limited its use in patients requiring full anticoagulation for venous thrombosis.Assess the safety of using anticoagulation with bevacizumab, we conducted a retrospective review of our patients who were treated with bevacizumab while receiving anticoagulation.Reviewed their medical records and imaging for signs of hemorrhage.Total, we had 21 patients who received anticoagulation and bevacizumab concurrently for a median time of 72 days.Patients had adequate anticoagulation for venous thrombosis.Were no frank lobar hemorrhages in any patient.Had small, intraparenchymal hemorrhages on MRI, but only one patient actually developed symptoms due to the hemorrhage.Patients had residual neurological deficits from the hemorrhages.More patients had evidence of a minor increase in signal on noncontrast T1-weighted sequence, presumed to be petechial hemorrhages, without any clinical sequelae or progression.Read more A doseГўВЂВ"response relationship research on botulinum toxin type a local intramuscular injections of lower extremity spasticity in children with cerebral palsy
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