RESEARCH WILL NEED TO EXAMINE THE BENEFICIAL VERSUS THE SIDE EFFECTS OF ARIPIPRAZOLE FOR TREATMENT OF ALCOHOL DEPENDENCE.Approved by the US Food and Drug Administration to treat bipolar disorder as well as schizophrenia.Study of aripiprazole's potential for treating alcohol dependence has found that it significantly and dose-dependently increases the sedative effects of alcohol and, to a lesser degree, decreases the euphoric effects of alcohol.Results are published in the April issue of _Alcoholism: Clinical receiving on the day before the laboratory session either no medication, or 2.Or 10 mg of aripiprazole.Each session, participants consumed three standard drinks, for a total of 0.Of alcohol for the men, and 0.For the women.Alcohol concentrations, heart rate, blood pressure, static ataxia (body sway), and subjective effects were measured regularly throughout the laboratory sessions."Findings show that aripiprazole made the drinkers sleepier and they experienced less pleasure from alcohol than they might have without it," said Kranzler."Aripiprazole might 'shift the balance' from alcohol being more stimulating to being more sedating," added Anton.Has implications for both treatment and side-effect management for people taking this medication, effects that make them not suitable for treatment of alcohol-use disorders.Might be more tolerated and have less long-term negative effects.Kranzler concurred.Antipsychotic drugs - such as haloperidol and, olanzapine, which are full dopamine antagonists - reduce the pleasurable effects of alcohol, but they are associated with more adverse effects than aripiprazole is.List of side effects associated with most medications that exert powerful enough effects to be of value in treating psychosis is long.Ones that occur substantially moremonly than with placebo are headaches, insomnia, nausea, dizziness, and vomiting."Aripiprazole is one of a growing list of medications that are being evaluated for the treatment of alcoholism," said Anton.Should really see this as preliminary evidence and should be on the lookout for more studies to inform them of the potential treatment utility of aripiprazole by itself or inbination with other medications for alcohol-use disorders.Suggested that future research test aripiprazole on heavier drinkers and non-treatment-seeking alcoholics under longer-term dosing and natural drinking conditions, and also explore potential genetic predictors of its stimulatory versus sedation effects, with and without alcohol."These findings help to demonstrate that alcohol has effects on many different brain chemicals and, as such, that many different treatment approaches for alcohol dependence may be useful," said Kranzler.Having been said, it's unclear whether aripiprazole will be very useful in this effort because its side effects may outweigh its beneficial effects.Would you like to for our weekly ?The end of each week we'll send you an email containing links to the most popular articles (by page impression) from your chosen categories that appeared on News-Medical.That week.Will NOT be bombarded with advertising and you CAN unsubscribe at any time.More information or click here to view our .News-Medical.The worthy medical information: .Child Health News Disease/Infection News Devices/Technology News Healthcare News Medical Conditions Medical Procedures Medical Patent News Medical Research News Men's Health News Medical Science News Miscellaneous News Pharmaceutical News Medical Studies/Trials Women's Health News < Jump to News-Medical.This medical news service in accordance with these .Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide.Read more Inhaled insulin loses support
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