MUZ, Nevin ILHAN, Gamze KRKL, Teyfik TURGUT, Nusret AKPOLAT (2008) Evaluation of the anti-inflammatory effect of infliximab in a mouse model of acute asthma doi:10.01278.Abstract ORIGINAL ARTICLE EVALUATION OF THE ANTI-INFLAMMATORY EFFECT OF INFLIXIMAB IN A MOUSE MODEL OF ACUTE ASTHMA Figen DEVECI, M.MUZ, Nevin ILHAN, Gamze KRKL, Teyfik TURGUT AND Nusret AKPOLAT Departments of 1Chest Diseases, 2Biochemistry and Clinical Biochemistry, and 3Pathology, Faculty of Medicine, Firat University, Elazig, Turkey Figen Deveci, Department of Chest Diseases, Faculty of Medicine, Firat University, 23119, Elazig, Turkey.EVALUATION OF THE ANTI-INFLAMMATORY EFFECT OF INFLIXIMAB IN A MOUSE MODEL OF ACUTE ASTHMA DEVECI F, MUZ MH, ILHAN N, KRKL G, TURGUT T, AKPOLAT N.2008 ABSTRACT Background and objective: To evaluate the potential role of anti-tumour necrosis factor (TNF)- mAb (infliximab) on the inflammatory response in a mouse model of acute asthma.Methods: BALB/c mice received intraperitoneal (i.Ovalbumin (OVA) on days 0 and 14, 100 g of OVA intranasally on day 14 and 50 g of OVA intranasally on days 25, 26 and 27.Low-dose (2.And high-dose (6.Infliximab groups received i.Infliximab before each i.Sensitization and on challenge days 1, 6, 13, 20 and 27.Group received i.Injections of normal saline with alum on days 0 and 14 and normal saline without alum on days 14, 25, 26 and 27.Results: There were statistically significant decreases in the numbers of BAL fluid (BALF) neutrophils, eosinophils, as well as lung eosinophils in both the low- and high-dose infliximab groups whenpared with the control OVA sensitized/challenged group.Lower dose of infliximab did not alter lung neutrophil counts, but a marked decrease was seen with the high dose of infliximab.Treatment with low and high doses of infliximab, BALF levels of regulated on activation normal T cell expressed and secreted (RANTES), granulocyte macrophage-colony stimulating factor (GM-CSF), TNF-, IL-6, macrophage inflammatory protein (MIP)-2, and levels of RANTES, IL-4, GM-CSF, TNF-, IL-6 and MIP-2 in lung tissue were significantly decreased whenpared with the control OVA sensitized/challenged group.Was a significant decrease in BALF IL-4 only in the high-dose infliximab group.Conclusions: These results show that an anti-TNF- mAb has a considerable anti-inflammatory effect on allergen-induced lung inflammation in an animal model of acute asthma.Read more Blood pressure drug 'cuts parkinson's risk' according to new research
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