You have forgotten your username or password, we can .My Menu Saved Items дёж–‡(з®ЂдЅ") дёж–‡(з№Ѓй«") English Deutsch н•њкµм–ґ ж—Ґжњ¬иЄћ Franais Espaol Ш§Щ„Ш№Ш±ШЁЩЉШ© Р СѓСЃСЃРєРёР№ Journal Article Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFО± therapy in rheumatoid arthritis?Publisher Springer Berlin / Heidelberg ISSN 0172-8172 (Print) 1437-160X (Online) Status Category Original Article DOI 10.Subject Collection SpringerLink Date Friday, February 29, 2008 G polymorphism predict the response grading to anti-TNF therapy in rheumatoid arthritis?Alessia Ongaro1 , Monica De Mattei1, Agnese Pellati1, Angelo Caruso1, Stefano Ferretti2, Federica Francesca Masieri1, Maria Fotinidi3, Ilaria Farina3, Francesco Trotta3 and Melissa Padovan3 (1) Department of Morphology and Embryology, Section of Histology, University of Ferrara, Via Fossato di Mortara, 64/B, 44100 Ferrara, Italy (2) Ferrara Cancer Registry, Department of Experimental and Diagnostic Medicine, Section of Anatomic Pathology, University of Ferrara, Via Fossato di Mortara, 64/B, 44100 Ferrara, Italy (3) Section of Rheumatology, Department of Clinical and Experimental Medicine, University of Ferrara, C.203, 44100 Ferrara, Italy RECEIVED: 10 December 2007 ACCEPTED: 18 February 2008 PUBLISHED ONLINE: 29 February 2008 Abstract In this study we analyzed whether the polymorphisms 676T>G in the tumor necrosis factor receptor (TNFR) II gene and -308G>A in the TNF promoter gene may influence the response grading to anti-TNF therapy in rheumatoid arthritis.And genotyped 105 RA patients treated with etanercept (_n_ = 55), infliximab (_n_ = 40) and adalimumab (_n_ = 10) for 1 year.Response was evaluated according to the ACR criteria every 3 months.With TNFRII 676TG genotype was significantly associated with lower ACR responsepared with 676TT genotype, at 3 (OR 3.CI 1.And 12 months (OR 4.CI 1.Of treatment.Association between TNF -308G>A polymorphism and the clinical response was found.676TG genotype is associated with a lower response to anti-TNF therapy, independently from the specific agent used.Polymorphism could be a useful genetic marker for predicting the different response grading to anti-TNF therapy.Rheumatoid arthritis - Anti-TNF therapy - TNFRII 676T Within all content Within this journal Export this article Export this article as RIS Text Text PDF The size of this document is 367.Although it may be a lengthier download, this is the most authoritative online format.HTML This offers the quickest access for ease of browsing.Note that some scientific and mathematical characters may not render as precisely as in PDF versions.В© Springer.Read more Sertraline/lorazepam: cleft palate (first report with sertraline) in a neonate following in utero exposure: case report
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