Contact us to report problems with: For Publishers For Researchers For Librarians HEPATIC EFFECTS OF LOVASTATIN EXPOSURE IN PATIENTS WITH LIVER DISEASE: A RETROSPECTIVE COHORT STUDY AUTHORS: Avins, Andrew L.Michele M.Lynn; Zhao, Wei; Murphy, Rosemary; Levin, Theodore R.Douglas J.Peggy M.Replogle, Amy; Levine, Jeffrey G.SOURCE: , Volume 31, Number 4, 2008 , pp.Key: - Free Content - New Content - Subscribed Content - Free Trial Content ABSTRACT: BACKGROUND: Little is known about the potential adverse hepatic effects of HMG-CoA reductase inhibitors (`statins') in patients with existing liver disease; therefore, we examined the risk of liver toxicity with lovastatin exposure in these patients.Retrospective cohort study was performed using data from a large integrated health plan in Northern California, USA.With laboratory or clinical evidence of liver disease were identified and their exposure to lovastatin was determined.Primary oue was a pattern of liver-test abnormalities associated with a poor prognosis among patients with drug-induced liver disease, based on Hy's Rule.Included liver injury (defined as moderate or severe, depending on the degree of ALT level elevations) or the development of either clinical cirrhosis or liver failure.Rate ratios (IRRs) were calculated and multivariate analyses conducted using extended Cox models.Total of 93106 patients met the entry criteria.Was associated with a lower incidence of all endpoints, including the primary oue (IRR = 0.CI 0.Liver injury (IRR = 0.CI 0.Severe liver injury (IRR = 0.CI 0.And the occurrence of either cirrhosis or liver failure (IRR = 0.CI 0.Adjustment for age and sex resulted in some attenuation of this reduction in incidence.Observed effects were generally consistent across a range of baseline liver-disease diagnoses and greater cumulative lovastatin exposure was associated with fewer oue events for some endpoints.This retrospective analysis, exposure to lovastatin was not associated with an increased risk of adverse hepatic oues.Do not support concern regarding lovastatin-related hepatotoxicity in patients with existing liver disease.KEYWORDS: ; ; DOCUMENT TYPE: Research article AFFILIATIONS: 1: 1 Kaiser Permanente Division of Research, Oakland, California, USA 2: 5 Merck & Co.Point, Pennsylvania, USA Pressing the buy now button more than once may result in multiple purchases CREDIT/DEBIT CARD INSTITUTIONAL PAYMENT ACCOUNT OR Purchase later Key: - Free Content - New Content - Subscribed Content - Free Trial Content Website 2008 Ingenta.Read more Are coenzyme q10 and fish oils safe in type 2 diabetics?
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