From Toronto Western Hospital in Ontario, and colleagues studied 59 psoriatic arthritis patients treated with methotrexate for at least 24 months between 1994 and 2004.Average age was 46 years, their average duration of psoriasis was 8 years, and they had an average of 12.Joints, the team reports in the _Journal of Rheumatology_.Increase in radiographic peripheral joint damage score during treatment was 1.68% of patients experienced at least a 40% reduction in the number of actively inflamed joints.A similar study conducted by the team between 1978 and 1993 showed that methotrexate now tends to be used earlier and at a higher dose.In the older study experienced greater radiographic progression (2.And just 48% achieved at least a 40% reduction in the number of actively inflamed joints.Now a need to re-evaluate the proper role of methotrexate in psoriatic arthritis with regard to newer biologic agents, especially in early disease," the team writes.Apanying editorial, Lesley Saketkoo and colleagues from Louisiana State University in New Orleans said that the study has "reinforced the potential that lies untapped within methotrexate and disease modifying antirheumatic drugs (DMARDs) in general.Read more The effect of daily valacyclovir suppression on herpes simplex virus type 2 viral shedding in hsv-2 seropositive subjects without a history of genital herpes.
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