WONG,, S.M.P.G.M.W.Of Psychiatry, Ludwig-Maximilians-University, Munich, Germany 2Department of Psychiatry, Martin-Luther-University, Halle-Wittenberg, Germany 3Psychiatric Hospital, Halle (Saale), Germany 4Private Hospital, Meiringen, Switzerland ABSTRACT _Aim:_ Alcoholism has been associated with long-lasting alterations in LHPA (limbic-hypothalamus-pituitary-adrenal) axis function, related to a dysfunction of the serotonergic neurotransmission.Of the serotonin system were previously reported to have significant influence on serotonin-induced neuroendocrine response.The study is to investigate in a double-blind, placebo-controlled approach, whether citalopram (a selective serotonin reuptake inhibitor, SSRI) would affect LHPA axis function as measured with ACTH (adrenocorticotrophic hormone) levels representing endocrine responsivity in 11 alcohol-dependent individualspared to 12 controls.Wanted to know whether functional polymorphisms (5-HTTLPR and 5HT2C Ser23Cys), have any influence on this responsivity.And Methods:_ Alcohol-dependent inpatients aged 36.Years who were de-toxified, withoutorbid psychiatric/medical disorders or concurrent psychotropic medications, and 12 age-matched healthy controls aged 32.Years were enrolled.Also reported their subjective experiences like anxiety, craving and intoxication using visual analogue scales (VAS), side-effects were assessed by the serotonin syndrome scale (SSS).Were taken at 8 timepoints at 30 mins interval, from -2 (60 mins pre-application) to +6 (180 mins post-application).Had a mean duration of illness of 8.Consumed a mean of 326.G alcohol/day whereas control subjects consumed a mean of 32.G alcohol/day.0.Citalopram/kg body weight dose was administered intravenously to patients (31.Mg), and to controls (34.Mg)._Results:_ ACTH levels were higher for both groups in the verumpared to placebo administrations across timepoints.Ser23 alleles effected significantly higher ACTH responses under placebo administration but attenuated the responses under citalopram adminsitration.Both groups together, no influence of 5-HTTLPR alleles was found on ACTH levels in either group under either regimen.Citalopram adminsitration did not reduce craving in alcohol-dependent patients, it increased anxiety in patients and controlspared to placebo adminstration._Conclusion:_ Despite the small differences in endocrine and subjective responses between alcoholic patients and controls, the effect of SSRI on endocrine response with respect to 5HT2C functional alleles deserves further investigation in larger samples to clarify whether this genetic variant constitutes a potential risk factor for changes in neuroendocrine functioning and subsequent psychiatric disorders.In (53 kb) (186 kb) Andere Ausgabe whlen: Jahr2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 Seite1-39 (01)41-79 (02) Service Thieme-connect ist ein Service des und .Read more Teva announces tentative approval of generic prevacid® delayed-release capsules
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