SILVIA PADDOCK, PH.HUSSEINI MANJI, M.A.M.ALEXANDER F.PH.DENNIS CHARNEY, M.AND FRANCIS J.M.Suicidal ideation is an umon symptom than can emerge during antidepressant treatment.Biological basis of treatment-emergent suicidal ideation is unknown.Markers may shed light on the causes of treatment-emergent suicidal ideation and help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, or specialty care.A clinically representative cohort of outpatients with major depressive disorder who enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STARD) trial were treated with citalopram under a standard protocol for up to 14 weeks.Samples from 1,915 participants were genotyped for 768 single-nucleotide polymorphisms in 68 candidate genes.And genotype frequencies werepared between the 120 participants who developed treatment-emergent suicidal ideation and those who did not.Two markers were significantly associated with treatment-emergent suicidal ideation in this sample (marker rs4825476, p = 0.Ratio = 1.= 0.Rs2518224, p = 0.Ratio = 8.P = 0.These markers reside within the genes GRIA3 and GRIK2, respectively, both of which encode ionotropic glutamate receptors.Markers within GRIK2 and GRIA3 were associated with treatment-emergent suicidal ideation during citalopram therapy.Replicated, these findings may shed light on the biological basis of this potentially dangerous adverse event and help identify patients at increased risk.(REPRINTED WITH PERMISSION FROM THE AMERICAN JOURNAL OF PSYCHIATRY 2007; 164:1530-1538) Dr.Has served as an adviser, consultant, or speaker for or received research support from Advanced Neuromodulation Systems, Best Practice Project Management, Bristol-Myers Squibb, Cyberonics, Eli Lilly, Forest Pharmaceuticals, Gerson Lehman Group, GlaxoSmithKline, Healthcare Technology Systems, Jazz Pharmaceuticals, Merck, NIMH, Neuronetics, Ono Pharmaceutical, Organon USA, Personality Disorder Research Corp.The Robert Wood Johnson Foundation, the Stanley Medical Research Institute, the Urban Institute, and Wyeth-Ayerst Laboratories.Has equity holdings in Pfizer and receives royalty/patent ie from Guilford Publications and Healthcare Technology Systems.Charney has served as an adviser, consultant, or speaker for or received research support from Astra-Zeneca, Bristol-Myers Squibb, Cyberonics, Forest Laboratories, Gene-Logic, Institute of Medicine, Neuroscience Education Institute, Novartis, Organon International, and Quintiles, Inc.Laje, Paddock, Manji, Rush, Wilson, and McMahon are listed as co-inventors on a provisional patent application related to the findings in this article that was filed on October 27, 2006.Other authors report nopeting interests.Get information about faster international access.Read more First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis
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