IQBAL, A.N.M.S.J.Of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, Illinois, USA 2Department of Clinical Nutrition, Rush University Medical Center, Chicago, Illinois, USA ABSTRACT A number of human and animal studies using conjugated linoleic acids (CLA) or diacylglycerol (DAG) oil have shown positive physiological effects on abdominal adiposity, plasma triglycerides, plasma glucose, and insulin sensitivity.Novel DAGposition containing CLA called CLA diacylglyceride (CLA-DAG) may offer potential as a therapeutic agent in reducing some of the symptoms associated with the diabetic phenotype and metabolic syndrome.Study was designed to investigate the effect of CLA-DAG oil on the diabetic phenotype in male Zucker diabetic fatty rats.Were assigned to one of four groups: control (C), rosiglitazone (ROS), CLA-DAG, or CLA as free fatty acid (CLA-FFA).11 weeks, body weight was higher and kidney weight was lower in the CLA-DAG and ROS groupspared with the C group.ROS treatment increased the percentage of body fat aspared with all other groups.Fasting blood glucose was lower in the CLA-DAG and ROS groups than in the C group.Cholesterol was lower in the CLA-DAG group, and plasma triglycerides were lower in the ROS grouppared with the C group.Also observed changes in transcript abundance of PPAR-Оі, PPAR-О±, FAS, LPL, UCP2, UCP3, CPT1, RxR, ObRb, ApoAII, ApoD, and IRS1 in liver, muscle, and adipose tissue, suggesting treatment-induced effects on these genes.Data suggest the need for further research on the therapeutic relevance of CLA-DAG oil in obesity and diabetes.Research should also differentiate between CLA alone and DAG alonepared with thebination.KEY WORDS transcript abundance - liver - muscle tissue - adipose tissue - metabolic syndrome Volltext in (60 kb) (212 kb) Andere Ausgabe whlen: Jahr2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 Seite1-71 (01)73-161 (02) Service Thieme-connect ist ein Service des und .Read more Dexcom(tm) announces joint development agreement with animas corporation
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