ARTICLE LINKS: THE EFFECT OF DAILY VALACYCLOVIR SUPPRESSION ON HERPES SIMPLEX VIRUS TYPE 2 VIRAL SHEDDING IN HSV-2 SEROPOSITIVE SUBJECTS WITHOUT A HISTORY OF GENITAL HERPES.ARTICLE Sexually Transmitted Diseases.March 2008.Sperling, Rhoda S.Fife, Kenneth H.+; Warren, Terri J.++; Dix, Lynn P._ ABSTRACT: Background: A substantial number of HSV-2 seropositive individuals lack a history of clinically recognized genital herpes.Individuals can transmit disease during periods of asymptomatic viral shedding.Frequency of asymptomatic shedding and the efficacy of antiviral therapy in reducing shedding has not been assessed in this population.The effect of valacyclovir 1 g once daily for 60 days versus placebo on asymptomatic viral shedding in immunpetent, HSV-2 seropositive subjects without a history of symptomatic genital herpes infection.Seventy-three subjects were randomized to receive valacyclovir 1 g daily or placebo for 60 days each in a 2-way crossover design.Daily swab of the genital area was self-collected for HSV-2 detection by polymerase chain reaction.Read more Periogard(chlorhexidine gluconate) liquid [colgate oral pharmaceuticals inc.]
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