Pilot service has been created to help members of the primary care teams of England get answers to their clinical questions.This is the first visit to the site we rmend you read "".View by speciality MOST RECENT QUESTIONS: (Please click on a question for the answer) Are Coenzyme Q10 and fish oils safe in type 2 diabetics?INTERPRETATION: Initial question: An overweight pt with type 2 Diabetes and hypertension has seen a 'nutritional therapist ' who rmends CoQ10 width:100%;" class="answer" style="font-family:Arial;"> Cochrane have very recently (November 2007) published the systematic review 'Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus' .Sub-heading for the review was: _"There is not enough evidence to say whether the benefits of taking omega-3 fats in type 2 diabetes mellitus exceed the harms for this group of people"_ While the actual conclusion was: _"Omega-3 PUFA supplementation in type 2 diabetes lowers triglycerides and VLDL cholesterol, but may raise LDL cholesterol (although results were non-significant in subgroups) and has no statistically significant effect on glycemic control or fasting insulin.With vascular events or mortality defined endpoints are needed.The American National Centre forplementary and Alternative Medicine have published a review of type 2 diabetes and dietary supplements and this discusses both fish oils and coenzyme Q10.Be noted that this was published before Cochrane published their updated review.The section on fish oil is too large to reproduce here, but we'll highlight a few passages we feel are more pertinent: _"Another analysis was published in 2004 by the Agency for Healthcare Research and Quality, of 18 studies on omega-3 fatty acids for a number of measurable oues in type 2 diabetes.Study confirmed virtually all the Cochrane authors' findings, except for finding no significant effect on LDL cholesterol._"Omega-3s appear to be safe for most adults at low-to-moderate doses.Have been some safety questions raised about fish oil supplements, because certain species of fish can be contaminated with substances from the environment, like mercury, pesticides, or PCBs._"Fish oil in high doses can possibly interact with, and affect the action of, certain medications, including blood-thinning drugs and drugs for high blood pressure.With regard to coenzyme Q10 they report: _"Coenzyme Q10, often referred to as CoQ10 (sometimes written as CoQ10; other names include ubiquinone and ubiquinol) is a vitamin-like substance.Cells make energy and acts as an antioxidant.Seafood contain small amounts of CoQ10.Are marketed as tablets and capsules.Summary of the research findings There have been few studies on CoQ10 and type 2 diabetes so far.Evidence is not sufficient to evaluate CoQ10's effectiveness as a CAM therapy in diabetes.Has not been shown to affect blood glucose control.It might have use against heart disease in people with diabetes, but well-designed studies looking at heart disease oues are needed to answer this question.Side effects and other risks CoQ10 appears to be safe for most of the adult population.It may interact with and affect the action of some medicines, including warfarin (a blood thinner) and medicines used for high blood pressure or cancer chemotherapy.Possible side effects of CoQ10 include nausea, vomiting, diarrhea, loss of appetite, and heartburn.1) 2) The NLH Question Answering Service aims to answer questions quickly, it is not a systematic review.You have any doubt as to the implications of this contact the Q&A Service Provider for further information.Read more Copd patient benefits from treatment with seretide
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