Pages 1805-1816 (doi:10.1805) An alternative topical treatment of osteoarthritis of the knee with cutaneous diclofenac solutionIik zgneyUniversity of Ege, Department of Pharmaceutical Technology, Faculty of Pharmacy, 35100 Bornova, Izmir, Turkey +90 232 343 4000/5132; +90 232 388 5258; _Background_: Osteoarthritis (OA) is the mostmon chronic degenerative disease, which is characterised by the destruction of the articular cartilage and subchondral bone.Treatment of OA is based primarily on the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics.Are disadvantages to routinely using NSAIDs in OA.NSAIDs represent a potentially important advance in this regard as they may be significantly safer than oral NSAIDs.Solution (Pennsaid(R)) was developed for the treatment of symptomatic OA of the knee and contains diclofenac sodium as an active ingredient and dimethyl sulfoxide (DMSO), a penetration enhancer.To review: i) dermal drug application; ii) the treatment of OA with systemic and topical NSAID therapies; and iii) the clinical efficiency of Pennsaid on the topical treatment of OA of the knee.A literature search was carried out on skin, topical drug delivery, treatment of OA and assessment of published clinical studies with Pennsaid.Read more Bacteria Mix in Guts of Babies Predicts Obesity (HealthDay)
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