Published April 15, 2008; doi:10. 0193-1849/08 $8.Versions of this Article: 294/6/E1127 _most recent_ Services Google Scholar PubMed EFFECT OF GH ON HUMAN SKELETAL MUSCLE LIPID METABOLISM IN GH DEFICIENCY ROMAN TREPP,1 MARTIN FLCK,3 CHRISTOPH STETTLER,1 CHRIS BOESCH,2 MICHAEL ITH,2 ROLAND KREIS,2 HANS HOPPELER,3 HANS HOWALD,3 JEAN-PAUL SCHMID,4 PETER DIEM,1 AND EMANUEL R._ 1Division of Endocrinology, Diabetology and Clinical Nutrition, Inselspital, Bern University Hospital and University of Bern; 2Department of Clinical Research (Magnetic Resonance Spectroscopy and Methodology), University of Bern; 3Department of Systematic Anatomy; and 4Cardiovascular Prevention and Rehabilitation, Department of Cardiology, Inselspital, University of Bern, Bern, Switzerland _ Submitted 4 January 2008 ; accepted in final form 13 April 2008 Adult-onset growth hormone (GH) deficiency (GHD) is associated with insulin resistance and decreased exercise capacity.(IMCL) depend on training status, diet, and insulin sensitivity.Resonance spectroscopy, we studied IMCL content following physical activity (IMCL-depleted) and high-fat diet (IMCL-repleted) in 15 patients with GHD before and after 4 mo of GH replacement therapy (GHRT) and in 11 healthy control subjects.Insulin resistance and exercise capacity were performed and skeletal muscle biopsies were carried out to assess expression of mRNA of key enzymes involved in skeletal muscle lipid metabolism by real-time PCR and ultrastructure by electron microscopy.Control subjects, patients with GHD showed significantly higher difference between IMCL-depleted and IMCL-repleted.Resulted in an increase in skeletal muscle mRNA expression of IGF-I, hormone-sensitive lipase, and a tendency for an increase in fatty acid binding protein-3.Microscopy examination did not reveal significant differences after GHRT.Variation of IMCL may be increased in patients with GHDpared with healthy control subjects.Changes within the skeletal muscle (i.An increase in free fatty acids availability from systemic and/or local sources) may contribute to the increase in insulin resistance and possibly to the improvement of exercise capacity after GHRT.Upregulation of IGF-I mRNA suggests a paracrine/autocrine role of IGF-I on skeletal muscle.Intramyocellular lipids; insulin resistance; magnetic resonance spectroscopy; exercise capacity Address for reprint requests and other correspondence: E.Read more Amlodipine/valsartan: fixed-dose combination in hypertension
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