Pilot service has been created to help members of the primary care teams of England get answers to their clinical questions.This is the first visit to the site we rmend you read "".IMPORTANT ANNOUNCEMENT: As of June 27th the NLH Q" name="updateContentForm"> Can you tell me whether there is any interaction between orlistat and oral contraceptives?10/Jun/08 ANSWER: In October 2007 the Faculty of Sexual and Reproductive Healthcare answered the question 'For women using oral contraceptives is it safe to use Orlistat?They gave the following answer: _"Orlistat (marketed under the trade name Xenical) also known as tetrahydrolipstatin, is a drug designed to treat obesity.Is the saturated derivative of lipstatin—a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini.Primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake.To the summary of product characteristics for Orlistat (Xenical), no interactions with oral contraceptives have been observed.Does not suggest any interaction between hormonal contraceptives and Orlistat.Could not find any evidence of adverse reactions or loss of efficiency of oral contraceptives due to the drug interactions with Orlistat.The CEU suggests that it is safe to use Orlistat while using oral contraceptives.The CKS guideline on contraception reports: _"Orlistat:_ - Although no interactions between COCs and orlistat have been demonstrated in specific studies, orlistat may indirectly reduce the availability of COCs and lead to unexpected pregnancies in some cases .An additional contraceptive method is rmended if the woman has severe diarrhoea whilst taking orlistat.The CKS guideline on obesity uses slightly different wording: _"No direct interaction between oral contraceptives and orlistat has been demonstrated in specific drug-drug interaction studies.May indirectly reduce the availability of oral contraceptives through its action on the gastrointestinal tract.A woman experiences severe diarrhoea whilst taking orlistat an additional contraceptive method is rmended .REFERENCES 1) 2) 3) The NLH Question Answering Service aims to answer questions quickly, it is not a systematic review.You have any doubt as to the implications of this contact the Q&A Service Provider for further information.Read more [protein synthesis, post-translational modification, and degradation] opposite regulation of cd36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake
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