Antipressor action of L-Type calcium channel antagonist, nifedipine, has been studied when it was injected into the third ventricle prior to angiotensin II.Influence of nitric oxide on nifedipine antipressor action has also been studied by utilizing NW-nitro-L-arginine methyl ester (LNAME ) (40ug/0.Nitric oxide synthase inhibitor and L-arginine (20ug/0.Nitric oxide donor agent.Male Holtzman rats weighting 200-250 g, with cannulae implanted into the third ventricle were injected with angiotensin II.Produced an elevation in mean arterial pressure and a decreased in heart rate.Effects were potentiated by the prior injection of LNAME.And nifedipine blocked the effects of angiotensin II.Data showed the involvement of L-Type calcium channel and a free radical gas nitric oxide in the central control of angiotensin II-induced pressor effect.Suggested that L-Type calcium channel of the circunventricular structures of central nervous system participated in both short and long term neuronal actions of ANG II with the influence of nitrergic system.Read more The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis
Get more The First Web 2.0 Pharmaceutical News Portal
