You have forgotten your username or password, we can .My Menu Saved Items дёж–‡(з®ЂдЅ") дёж–‡(з№Ѓй«") English Deutsch н•њкµм–ґ ж—Ґжњ¬иЄћ Franais Espaol Ш§Щ„Ш№Ш±ШЁЩЉШ© Р СѓСЃСЃРєРёР№ Journal Article THE EFFECT OF OMEPRAZOLE ON ULTRASTRUCTURAL CHANGES IN GASTRIC PARIETAL CELLS Journal Publisher Springer Japan ISSN 0944-1174 (Print) 1435-5922 (Online) Issue Category Original Article DOI 10.Pages 1-8 Subject Collection SpringerLink Date Thursday, June 26, 2008 ORIGINAL ARTICLE The effect of omeprazole on ultrastructural changes in gastric parietal cells Hiroyuki Karasawa1 , Norio Tani1 and Takeshi Miwa1 (1) Department of Internal Medicine, Tokai University School of Medicine, Bohseidai, Isehara, 259-11 Isehara, Japan RECEIVED: 17 July 1987 ACCEPTED: 8 August 1987 Summary This study was designed topare the effects of omeprazole and cimetidine on ultrastructural changes in parietal cells of guinea pigs during histamine stimulation.And cimetidine remarkably inhibited acid secretion induced by histamine stimulation.However, failed to prevent the morphological transition of parietal cells to an active stage during histamine stimulation, in contrast to cimetidine which inhibited the morphological transition.Addition, it was noticed that administration of omeprazole caused vacuolation in approximately 27% of all parietal cells.Phenomenon was not seen in control animals with histamine stimulation alone and only very rarely in cimetidine treated animals.Findings suggested that vacuoles originated in secretory canaliculi of parietal cells.Results may be the key to explain the difference of the inhibitory mechanism between omeprazole which acts on the final step of the intracellular process (so-called proton pump) and cimetidine which acts on the H2-receptor site of plasma membrane.Key Words Cimetidine - H+/K+ATPase - Omeprazole - Parietal cell - Vacuolation References secured to subscribers.Find Query Builder Close Clear Within all content Within this journal Within this issue Export this article Export this article as RIS Text В© Springer.Read more Merck wins appeal of first vioxx(r) case to go to trial
Get more Vitamin E Supplements May Raise Lung Cancer Risk (HealthDay)
