Chem.283, Issue 25, 17227-17237, June 20, 2008 This Article All Versions of this Article: 283/25/17227 _most recent_ Services Google Scholar PubMed Related Collections Social Bookmarking DETERMINANTS OF CYTOCHROME P450 2C8 SUBSTRATE BINDING STRUCTURES OFPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID GUILLAUME A.JASON K.STEFAAN SANSEN, PATRICK M.DAVID STOUT, AND ERIC F.From the Departments of Molecular and Experimental Medicine and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037 and the Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS UMR 8601, Universit Paris Descartes, 45 Rue des Saints Pres, 75270 Paris Cedex 06, France Although a crystal structure and a pharmacophore model are available for cytochrome P450 2C8, the role of protein flexibility and specific ligand-protein interactions that govern substrate binding are poorly understood.Crystal structures of P450 2C8 This work was supported, in whole or in part, by National Institutes of Health Grant GM031001 (to E.J.This work was also supported by Pfizer Global Research and Development and the Sam and Rose Stein Charitable Trust.Of this work were carried out at the Stanford Synchrotron Radiation Laboratory, a national user facility operated by Stanford University on behalf of the United States Department of Energy, Office of Basic Energy Sciences.Synchrotron Radiation Laboratory Structural Molecular Biology Program is supported by the United States Department of Energy, Office of Biological and Environmental Research, by the National Center for Research Resources Biomedical Technology Program, and by NIGMS, National Institutes of Health.Costs of publication of this article were defrayed in part by the payment of page charges.Article must therefore be hereby marked "_advertisement_" in accordance with 18 U.Section 1734 solely to indicate this fact.The on-line version of this article (available at ) contains supplemental material.This article was selected as a Paper of the Week.1 Present address: F.Roche Ltd.Discovery Research Basel, CH-4070 Basel, Switzerland.2 Present address: Dept.Structural Biology, Takeda San Diego, San Diego, CA 92121.3 To whom correspondence should be addressed: Dept.Molecular and Experimental Medicine, The Scripps Research Inst.N.Pines Rd.La Jolla, CA 92037.Read more Revlimid(lenalidomide) capsule [celgene corporation]
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