Usually given at a dose of 1 mg/kg twice a day or 1.With a smaller dose of 1.Daily given to patients with a creatine clearance rate below 30 ml/minute, B Green (University of Queensland, Brisbane, Queensland, Australia) and co-workers explain.Results have suggested that anti-Xa levels could be optimized by adjusting enoxaparin doses for obesity and giving greater consideration to the extent of renal impairment.Further, the team randomly assigned 122 patients with pulmonary embolism, deep vein thrombosis, acute coronary syndromes, or atrial fibrillation to receive standard enoxaparin therapy or individualized enoxaparin treatment.Individualized doses, those weighing less than 100 kg based on their ideal (lean) body weight were given enoxaparin 1 mg/kg twice daily, while those weighing more than 100 kg were given enoxaparin 1.Twice daily.Renal impairment, defined as creatine clearance of less than 50 ml/minute, in the individualized treatment group were given standard treatment for the first 48 hours, followed by a fraction of the usual enoxaparin doses depending on creatine clearance.Ranged from 0.Dose in patients with a clearance of 10-19 ml/minute to 0.Dose for those with a rate of 40-49 ml/minute.That patients in the standard and individualized treatment groups did not significantly differ with regard to total body weight (74.Vs 76.Length of hospital stay (3.3.Per day (128 mg vs 137 mg), or average total dose (499 mg vs 464 mg).Events occurred in nine (15%) patients given standard enoxaparin therapypared with just one (2%) patient whose treatment was tailored (relative risk=0.Furthermore, while standard treatment was associated with three episodes of hematuria, three injection/venupuncture site bleeds, two hematemesis episodes, and one episode of epistaxis, just one case of hematemesis was reported among the individualized treatment patients.Read more Atorvastatin/grapefruit juice interaction: interaction leading to rhabdomyolysis: case report
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