Is released from the liver and plays an important role in childhood growth and continues to have anabolic effects in adults.In this study, researchers evaluated 376 healthy elderly men between the ages of 73 and 94 years.Serum sample was taken from each subject at the beginning of the study and researchers were contacted about the status of the participants over a period of eight years.Subjects with the lowest IGF-1 function had a significantly higher mortality rate than subjects with the highest IGF-1 bioactivity.Results were especially significant in individuals who have a high risk to die from cardiovascularplications.These new findingse as a result of a new form of testing for IGF-bioactivity.In this study used a new method, a bioassay, to measure the function of IGF-1 in the blood.Used methods to measure IGF-1, the IGF-1 bioassay gives more information about the actual function (bioactivity) of circulating IGF-1 in the body."The bioassay allowed us to more clearly see the association between high circulating IGF-1 bioactivity and extended survival," said Michael Brugts, MD, of the Erasmus Medical Center in Rotterdam, The Netherlands and lead author of the study.We could not find such a relationship when IGF-1 in blood was measured with the moremonly used methods.Used previously to determine IGF-1 circulation levels, remove certain proteins that interfere with accurate measurements.Studies however have found that these proteins are important modulators of IGF-1 bioactivity.Bioassay used in this study does not disregard or remove this protein, thus enabling researchers to have a more accurate understanding of IGF-1 function.Of IGF-1 function using the bioassay opens the possibility to gather new insights about the functions of IGF-1 in the body, said Brugts.JOURNAL REFERENCE: Brugts et al.CIRCULATING IGF-I BIOACTIVITY IN ELDERLY MEN IS ASSOCIATED WITH INCREASED MORTALITY.Of Clinical Endocrinology DOI: _Adapted from materials provided by , via , a service of AAAS_.Need to cite this story in your essay, paper, or report?One of the following formats: APA MLA RELATED STORIES (Jun.2005) A randomized UCLA study found that a new dosing paradigm can improve height oues in the treatment of children who have short stature due to growth hormone deficiency and idiopathic short .> (Apr.2005) Deficiencies of growth hormone and similarpounds may reduce cancer and kidney disease late in life, but also may lead to cartilage degeneration and impaired memory and learning ability, .> (Feb.2002) Growth-hormone therapy in elderly patients increases lean body mass and reduces body fat, helping them maintain fitness.Scientists say, the therapy also may dramatically boost the production of .> (Mar.2008) Testosterone deficiency, previously recognized asmon in men with type 2 diabetes, is alsomon in men with type 1 diabetes according to a new study.Findings suggest that there is a .> _Number of stories in archives: 44,032_ _Find with keyword(s):_ Enter a keyword or phrase to search ScienceDaily's archives for related news topics, the latest news stories, reference articles, science videos, images, and books.IN: Studying childhood cancer patients who have suffered tissue and organ damage from chemotherapy treatments, researchers have found that growth.._.From _ __ IN OTHER NEWS . __ _Copyright Reuters 2008.._.From _ Get the latest science news with our free email newsletters, updated daily and weekly.View hourly updated newsfeeds in your RSS reader: FEEDBACK _.We want to hear from you!Tell us what you think of the new ScienceDaily we wee both positive and negativements.Read more Seven az products to enter discount not deducted list
Get more [transcription, chromatin, and epigenetics] estrogen induces estrogen-related receptor {alpha} gene expression and chromatin structural changes in estrogen receptor (er)-positive and er-negative breast cancer cells
