Influence of azithromycin and clarithromycin on macrolide susceptibility of viridans streptococci from the oral cavity of healthy volunteers

You have forgotten your username or password, we can .My Menu Saved Items дё­ж–‡(з®ЂдЅ") дё­ж–‡(з№Ѓй«") English Deutsch н•њкµ­м–ґ ж—Ґжњ¬иЄћ Franais Espaol Ш§Щ„Ш№Ш±ШЁЩЉШ© Р СѓСЃСЃРєРёР№ Journal Article INFLUENCE OF AZITHROMYCIN AND CLARITHROMYCIN ON MACROLIDE SUSCEPTIBILITY OF VIRIDANS STREPTOCOCCI FROM THE ORAL CAVITY OF HEALTHY VOLUNTEERS Journal Publisher Springer Berlin / Heidelberg ISSN 0934-9723 (Print) 1435-4373 (Online) Category Article DOI 10.Subject Collection SpringerLink Date Friday, May 30, 2008 ARTICLE Influence of azithromycin and clarithromycin on macrolide susceptibility of viridans streptococci from the oral cavity of healthy volunteers M., C.M.R.H.H.Wagner1 and H.(1) Institute for Microbiology and Hygiene, CharitГ©University Medicine Berlin, Campus Benjamin Franklin, Free University and Humboldt University Berlin, Hindenburgdamm 27, 12203 Berlin, Germany (2) Department of Respiratory Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany (3) Department of Biostatistics and Clinical Epidemiology, CharitГ©University Medicine Berlin, Campus CharitГ© Mitte, Free University and Humboldt University Berlin, Luisenstr.10117 Berlin, Germany (4) Department of Chest and Infectious Diseases, Helios Klinikum Emil von Behring, Zum Heckeshorn 33, 14109 Berlin, Germany RECEIVED: 17 January 2008 ACCEPTED: 28 April 2008 PUBLISHED ONLINE: 30 May 2008 Abstract Oral viridans streptococci are a reservoir of resistance genes for pathogens.Prolonged exposure, long-acting macrolides (e.Azithromycin) may induce the resistance of themensals to macrolides more frequently than macrolides with a shorter half-life (e.Clarithromycin).A prospective, randomized, evaluator-blinded trial in healthy volunteers receiving standard courses of either azithromycin (_n_=20) or clarithromycin (_n_=20), wepared the susceptibility of oral viridans streptococci to macrolides over a period of 12 weeks.Was a significant temporal increase in the numbers of resistant isolates in both groups (_p_ Within all content Within this journal Export this article Export this article as RIS Text В© Springer.
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