You have forgotten your username or password, we can .My Menu Saved Items дёж–‡(з®ЂдЅ") дёж–‡(з№Ѓй«") English Deutsch н•њкµм–ґ ж—Ґжњ¬иЄћ Franais Espaol Ш§Щ„Ш№Ш±ШЁЩЉШ© Р СѓСЃСЃРєРёР№ Journal Article IBD AND IBD MIMICKING ENTEROCOLITIS IN CHILDREN YOUNGER THAN 2В YEARS OF AGE Journal Publisher Springer Berlin / Heidelberg ISSN 0340-6199 (Print) 1432-1076 (Online) Category Original Paper DOI 10.Subject Collection SpringerLink Date Wednesday, June 11, 2008 ORIGINAL PAPER IBD and IBD mimicking enterocolitis in children younger than 2 years of age Z.I.S.I.N., S.A.2 (1) Department of Reproduction and Development Sciences, University of TriesteIRCCS Burlo Garofolo, Trieste, Italy (2) Clinica Pediatrica, UniversitГ di TriesteIRCCS Burlo Garofolo, Via dell'Istria 65/1, 34134 Trieste, Italy RECEIVED: 28 October 2007 REVISED: 10 March 2008 ACCEPTED: 17 March 2008 PUBLISHED ONLINE: 11 June 2008 Abstract Inflammatory bowel disease (IBD) is umon in children younger than 2 years of age.Criteria for differentiating IBD from other diseases with similar clinical presentation is unclear.Describe 16 patients who, between 1984 and 2004, received a histological diagnosis of IBD during the first two years of life.Presented with histological Crohn's disease, eight with ulcerative colitis and two with indeterminate colitis.Median age at diagnosis was 125 days (range 1 day to 18 months) and the medium follow up was 89 months (range 65 days to 20 years).Disease appeared to be very severe: four children (25%) underwent total parenteral nutrition (TPN), two received colectomy (12.Three patients died.Of the patients required an aggressive, multidrug, immunosuppressive approach (azathioprine , Infliximab, thalidomide, cyclosporine A).Child presented with a hypogammaglobulinaemia without any specific immunodeficiency, while in the other patients, Wiskott-Aldrich syndrome (WAS) (4 cases) and chronic granulomatous disease (CGD) (2 cases) were identified.6/16 cases, allergic colitis was first considered; these cases initially underwent cow's milk protein-free diet as the only therapy before IBD was finally diagnosed.Conclusion, early IBD has a severe prognosis and often needs an aggressive therapeutic approach.An improper diagnosis of allergic colitis might cause an important diagnostic delay.Severe immunodeficiencies, such as WAS and CGD, may represent a problem in terms of differential diagnosis and might be wrongly diagnosed as very early onset IBD.Keywords IBD - Enterocolitis - Immunodeficiency N.EMAIL: References secured to subscribers.Find Query Builder Close Clear Within all content Within this journal Export this article Export this article as RIS Text В© Springer.Read more Rituximab added to six cycles of chemotherapy improves survival in elderly patients with aggressive lymphoma
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