The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis

You have forgotten your username or password, we can .My Menu Saved Items дё­ж–‡(з®ЂдЅ") дё­ж–‡(з№Ѓй«") English Deutsch н•њкµ­м–ґ ж—Ґжњ¬иЄћ Franais Espaol Ш§Щ„Ш№Ш±ШЁЩЉШ© Р СѓСЃСЃРєРёР№ Journal Article The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis Journal Publisher Springer Berlin / Heidelberg ISSN 0031-6970 (Print) 1432-1041 (Online) Status Category Clinical Trial DOI 10.Subject Collection SpringerLink Date Friday, December 28, 2007 CLINICAL TRIAL The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis Jaroslav ChlГЎdek1 , Marie SimkovГЎ2, Jaroslava VaneckovГЎ2, Milos Hroch3, Jirina ChlГЎdkova4, Jirina MartГ­nkovГЎ5, Jaroslava VГЎvrovГЎ6 and Martin BerГЎnek6 (1) Department of Pharmacology and Department of Biochemistry, Faculty of Medicine, Charles University, Simkova 870, 500 38 Hradec Kralove, Czech Republic (2) Department of Dermatology, University Hospital, Hradec Kralove, Czech Republic (3) Department of Pharmacology, Faculty of Medicine, Charles University, Hradec Kralove, Czech Republic (4) Department of Paediatrics, University Hospital, Hradec Kralove, Czech Republic (5) Department of Pharmacology, Faculty of Medicine, Charles University, Simkova 870, 500 38 Hradec Kralove, Czech Republic (6) Department of Clinical Biochemistry and Diagnostics, University Hospital, Hradec Kralove, Czech Republic RECEIVED: 2 October 2007 ACCEPTED: 3 December 2007 PUBLISHED ONLINE: 29 December 2007 Abstract Objective We assessed the effect of folic acid (FA) on the pharmacokinetics and pharmacodynamics of low-dose oral methotrexate (MTX) during the remission-induction phase of psoriasis treatment.Methods In a 32-week, open-label, two-way cross-over study, patients (_n_=20, seven men, aged 35-70 years) with moderate-to-severe plaque psoriasis were randomly assigned to receive MTX plus FA (20 mg/week) for 16 weeks followed by MTX monotherapy (three doses of MTX separated by 12-h intervals once a week) for an additional 16 weeks (treatment arm A, _n_=10) or to receive the opposite sequence of treatments (arm B, _n_=10).Of MTX was individualised with the help of pre-study evaluation of plasma MTX pharmacokinetics.Psoriasis Area and Severity Index (PASI), biochemistry and haematology tests and erythrocyte concentration of MTX polyglutamates (MTXPG) were evaluated throughout the study.In arms A and B, the mean (range) concentrations of MTXPG (nmol/L) wereparable .16 weeks, the meanВ±SEM PASI decreased from 20.To 8.In arm A, while a greater reduction from 27.To 5.In arm B (_P_ Within all content Within this journal Export this article Export this article as RIS Text Text PDF The size of this document is 202 kilobytes.It may be a lengthier download, this is the most authoritative online format.HTML This offers the quickest access for ease of browsing.Note that some scientific and mathematical characters may not render as precisely as in PDF versions.В© Springer.
Read more Stimulation of fecal fat excretion and the disposal of protoporphyrin in a murine model for erythropoietic protoporphyria
Get more [articles] cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a star*d report