Or contact us to report problems drug viagra cialis viagra vs with: For Publishers For Researchers For Librarians ATORVASTATIN: A PHARMACOECONOMIC REVIEW OF ITS USE IN THE PRIMARY AND SECONDARY PREVENTION OF CARDIOVASCULAR EVENTS AUTHORS: Plosker, Greg L.Katherine A.SOURCE: , Volume 25, Number 12, 2007 , pp.PUBLISHER: Key: - Free free viagra sample Content - New Content - Subscribed Content - Free Trial Content ABSTRACT: Atorvastatin is a lipid-lowering agent that has been evaluated in a number of primary and secondary intervention studies.Primary prevention trials ASCOT-LLA and CARDS, atorvastatin 10 mg/day significantly reduced cardiovascular buy online viagra eventspared with placebo.Conducted economic analysis of the 3.Trial showed cheapest online viagra that atorvastatin was associated with incremental cost-effectiveness ratios (ICERs) of euro11693 (UK) and euro12673 (Sweden) per event avoided (2002 values).Analyses using data from CARDS showed ICERs of euro8046 (Spain) and Ј6471 (UK) per QALY natural viagra gained (2003/2004 values), and a US analysis showed atorvastatin was dominant versus no statin when modelled over the lifetime of a representative US diabetic primary prevention population womens viagra .Modelled analysis based on results of the IDEAL trial, which showed significant reductions in cardiovascular endpoints with high-dose atorvastatin (80 mg/day)pared with conventional-dose simvastatin in patients with stable coronary heart disease, ICER values were cheapest price viagra below themonly used cost-effectiveness threshold of euro50000 per QALY gained in Norway, Sweden and Denmark, but were above this threshold in Finland (2005 values).Modelled US analysis that also included data from IDEAL and other sources showed an ICER of US33400 per QALY gained, assuming the incremental difference in acquisition viagra online consultation cost between high-dose atorvastatin and conventional-dose simvastatin was US1.Value).With atorvastatin in patients with acute viagra soft tab coronary syndrome used data from the 16-week MIRACL study, which showed a significant reduction in cardiovascular events with high-dose atorvastatinpared with placebo.Were conducted in North America and Europe and showed that 31-86% of the acquisition cost of high-dose atorvastatin was offset by reductions in costs associated with cardiovascular events.Five countries, ICER values ranged from US850 to US4100 per event avoided (2000/2001 values).Analysis conducted in the US used longer-term data and showed that high-dose atorvastatin versus conventional-dose statin was associated with an ICER of US12900 per QALY gained, assuming the daily difference in acquisition cost was US1.Value).Atorvastatin has demonstrated beneficial effects on various cardiovascular endpoints in large, well designed primary and secondary intervention trials.Benefits in moderate- to high-risk patients were achieved at a relatively low incremental cost and, across the economic analyses, a substantial proportion of atorvastatin acquisition costs was offset by reductions in healthcare resource use associated with cardiovascular events.Based on major clinical trialsparing atorvastatin with placebo, usual medical care, simvastatin or pravastatin have generally shown that atorvastatin is associated with favourable ICER values, often well belowmonly used cost-effectiveness thresholds.Analyses have the inherent limitation that projecting long-term oues beyond the time period of a clinical trial imparts a degree of uncertainty to the results.While some findings were sensitive to changes in model assumptions, such as the long-term benefits of statin therapy, most sensitivity analyses showed that results of the base-case analyses were robust to plausible changes in key parameters.A clear pattern is not evident from available data, intuitively, the value of atorvastatin would be expected to increase with the patients risk for serious cardiovascular events.; ; ; DOCUMENT TYPE: Research article AFFILIATIONS: 1: Wolters book guest viagra Kluwer Health Adis, Auckland, New Zealand, an editorial office of Wolters Kluwer Health, Conshohocken, Pennsylvania, USA The full text article is available for purchase 54.TAX Pressing the buy now button more than once may result in multiple purchases CREDIT/DEBIT CARD INSTITUTIONAL recreational use of viagra PAYMENT ACCOUNT OR Purchase later Key: - Free Content - New Content - Subscribed Content - Free Trial Content Website (c) 2007 Ingenta.
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