NDT ADVANCE viagra in the uk ACCESS ORIGINALLY PUBLISHED ONLINE ON JULY 4, 2007 Nephrology Dialysis Transplantation 2007 22(12):3573-3579; doi:10.This Article All Versions of this Article: 22/12/3573 _most recent_ Services Google Scholar PubMed __ PREDICTORS OF CARDIOVASCULAR EVENTS IN PATIENTS WITH END-STAGE RENAL DISEASE: AN ANALYSIS FROM THE FOSINOPRIL IN DIALYSIS STUDY Michle Kessler1, Faiez Zannad2, Philippe Lehert3, Jean Pierre Grnfeld4, Christian Thuilliez5, Alain Leizorovicz6, Philippe Lechat7 for the FOSIDIAL Investigators 1Department of Nephrology, University Hospital of Nancy, 2Hypertension and Preventive Cardiology Division, Department of Cardiovascular disease, Centre dInvestigations Cliniques INSERM-CHU, INSERM U684, Nancy, France, 3Faculty of Medicine, Melbourne, Australia and Faculty of Economics, FUCAM, Louvain Academy, Belgium, 4Department of Nephrology, Hpital Necker, Universit Paris V - Ren Descartes, Paris, 5Department of Clinical Pharmacology and Centre dInvestigations Cliniques INSERM-CHU, University Hospital of Rouen, 6Clinical Pharmacology Unit, EA 3736, Universit Claude Bernard Lyon 1, Lyon and 7Pharmacology Department, Piti-Salptrire University Hospital, Assistance-Publique Hpitaux de Paris, Paris 6 University, Paris, France _Correspondence and offprint requests to:_ Michle Kessler, MD, Service de Nphrologie, Hpitaux de Brabois alternative viagra woman , CHU de Nancy, 54500 Vandoeuvre les Nancy, France.M.ABSTRACT BACKGROUND.Events (CVE best price viagra viagra sale ) are a major cause of morbidity and mortality buying online viagra in end-stage renal disease (ESRD) patients.Are often excluded from CV clinical trials sale uk viagra , and the prognostic factors discount sale viagra associated with CVE in patients with ESRD have not been fully explored.Risk prediction model was created who use viagra from the FOSIDIAL trial to identify factors predictive of CVE and to evaluate the relative strength of known predictors when considered together in a multivariate model.METHODS.Was a prospective, randomized, double-blind study with 2-year follow-up and CVE adjudication.Enrolled 397 patients with ESRD and left ventricular hypertrophy (LVH).Included cardiovascular death, non-fatal myocardial infarction, unstable angina, stroke, revascularization, heart failure hospitalization, resuscitated cardiac arrest and confirmed stroke.Was built using a forward selection of all baseline variables.Equation model (SEM) was used to identify factors with an indirect association with CVE.RESULTS.History was the most important prognostic factor, followed by C-reactive protein (CRP), left ventricular mass index, diabetes and age.Low HDL, female gender and Kt/V were indirectly associated with CVE.CONCLUSION.Disease, elevated CRP, LVH, diabetes or advanced age identifies patients at the highest risk for CVE.Data may be useful to detect high risk patients, to define potential targets for pharmacologic intervention, and to plan future studies in ESRD.Is needed to identify effective approaches that reduce the rate of CVE in these patients.KEYWORDS: cardiovascular disease; end-stage renal disease; morbidity; mortality Received for publication: 12.Accepted in revised form: 4.
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