You have forgotten your username or password, we can .My Menu Saved Items дёж–‡(з®ЂдЅ") дёж–‡(з№Ѓй«") English Deutsch н•њкµм–ґ ж—Ґжњ¬иЄћ Franais Espaol Ш§Щ„Ш№Ш±ШЁЩЉШ© Р СѓСЃСЃРєРёР№ Journal Article Suppression of Pseudomonas aeruginosa alternative viagra _ quorum-sensing systems by macrolides: a promising strategy or an oriental mystery?Journal Publisher Springer Japan ISSN 1341-321X (Print) 1437-7780 (Online) Issue Category REVIEW ARTICLE comments.cgi female mt viagra DOI 10.Pages 357-367 Subject Collection SpringerLink Date Thursday, December 20, 2007 _Pseudomonas+aeruginosa_+Autoinducer+Diffuse+panbronchiolitis+Cystic+fibrosis" class="advertisementFrame"> REVIEW ARTICLE Suppression of _Pseudomonas aeruginosa_ quorum-sensing systems by macrolides: a promising strategy or an oriental mystery?Kazuhiro Tateda1 , Yoshikazu Ishii1, Soichiro Kimura1, Manabu Horikawa2, Shinichi Miyairi3 and Keizo Yamaguchi1 (1) Department of Microbiology and Infectious Disease, Toho University School of Medicine, 5-21-16 Ohmorinishi, Ohtaku, Tokyo 143-8540, Japan (2) Suntory Institute for Bioorganic Research, Osaka, Japan (3) Laboratory of Bio-organic Chemistry, College of Pharmacy, Nihon University, Chiba, Japan RECEIVED: 24 July 2007 PUBLISHED ONLINE: 25 December 2007 Abstract A breakthrough in antibiotic chemotherapy for patients with chronic _Pseudomonas aeruginosa_ pulmonary infections was brought about by findings in a patient with diffuse panbronchiolitis (DPB), who had been treated pharmaceutical female viagra with erythromycin over a period of years.Clinical trials have demonstrated that long-term macrolide therapy can be used not only for DPB patients but also for those with other chronic infections, including patients with cystic fibrosis (CF).Pathogenes viagra uk is of chronic _P.Is considered to arise from a bacterial cell-to-cell generic online pharmacy viagra signaling mechanism, named "quorum-sensing", which enables the bacteria to coordinately turn on and off their virulence genes through the production of autoinducer molecules.Evidence from clinical and basic science fields suggests the potential of macrolides as _Pseudomonas_ quorum-sensing inhibitors.This review, we briefly summarize the data on the clinical efficacy of macrolides in DPB and CF patients.Discuss the mechanisms of action of macrolides from the viewpoint of sub-minimum inhibitory concentration (sub-MIC) macrolide effects on _P.Particularly the potential activity of this antibiotic to suppress the bacterial quorum-sensing system.Key words Quorum-sensing system - Macrolide - _Pseudomonas aeruginosa_ - Autoinducer - Diffuse panbronchiolitis - Cystic fibrosis KAZUHIRO TATEDA EMAIL: References secured to subscribers.Find Query Builder Close Clear Within female viagra alternative all content Within this journal Within this issue Export this article Export this article as RIS Text Text PDF The size of this document is 618 kilobytes.It may be a lengthier download, this is the most chinese herbal viagra authoritative online format. В© Springer.
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