воскресенье, 20 января 2008 г.

Lovastatin sensitized human glioblastoma cells to trail-induced apoptosis.

, .Neurosurgery, bailiwick of Surgery, Prince of Wales The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China, wpoon@surgery. Synergy research with chemotherapeutic agents is amon in vitro strategy in the search after productive cancer cure exchange benefit of non-chemotherapeutic agents, effectual synergistic effects are umon.We have examined two non-chemotherapeutic agents after synergistic effects: lovastatin and Tumor Necrosis moneylender (TNF)- reciprocal apoptosis-inducing ligand (TRAIL) after synergistic effects; on three Possibly manlike malignant glioblastoma cubicle lines, M059K, M59J, and A172.Treated with lovastatin with the addition of way after 48 h showed 50% apoptotic cubicle extirpation whereas way unassisted (1,000 ng/ml) did not, suggesting that lovastatin sensitized the glioblastoma cells to way disparagement cubicle analysis indicated that lovastatin increased G(0)-G(1) seize in these cells.
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