All Versions of this Article: 101/1/65 _most recent_ Services viagra Google Scholar PubMed IDENTIFICATION OF A TRANSCRIPTIONAL FINGERPRINT OF ESTROGEN EXPOSURE IN RAINBOW TROUT LIVER ABBY D.AND DAVID E. Department generic order viagra of Environmental and 1 buy viagra Molecular viagra line Toxicology, the Marine and Freshwater Biomedical Sciences Center and the Environmental Health Sciences Center, 1007 Agricultural and Life Sciences Building, Corvallis, Oregon 97331 Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, Oregon 97331 1 To whom correspondence should be addressed at Department of Environmental and Molecular Toxicology, the Marine and Freshwater Biomedical Sciences Center and the Environmental Health Sciences Center, 1007 Agricultural and Life Sciences Building, Corvallis, Oregon 97331.(541) 737-7966.Edu.July 12, 2007; accepted August 31, 2007 ABSTRACT The goal of this study was to identify a set of hepatic genes regulated by ligand-dependent activation of the estrogen viagra sex story receptor in juvenile rainbow trout (_Oncorhynchus mykiss_).Custom rainbow trout oligo DNA microarray, which contains probes targeting approximately 1450 genes relevant to carcinogenesis, toxicology, endocrinology, and stress physiology was utilized to identify transcriptional fingerprints of _in vivo_ dietary exposure to 17-estradiol herbal viagra viewattachedhtml (E2), tamoxifen (TAM), estradiol + tamoxifen (E2 + TAM), diethylstilbestrol (DES), dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), and cortisol (CORT).Exposure altered the expression of up to 49 genes involved in reproduction, immune response, cell growth, transcriptional regulation, protein effects from side viagra synthesis and modification, drug metabolism, redox regulation, and signal transduction.DES, and DHEA regulated 18 genes inmon, mostly those associated with vitellogenesis, cell proliferation, and signal transduction.Uniquely regulated severalplementponent genes of importance to immune response.The effect of TAM on E2-induced changes in gene expression was mostly antagonistic, TAM alone increased expression of VTG1 and other genes associated with egg development and immune response.Genes responded to CORT treatment, and DHT significantly altered expression of only one gene targeted by the OSUrbt array.Cluster and principalponents analyses revealed distinct patterns of gene expression corresponding to estrogens and non-estrogens, though unique patterns could also be detected for individual chemicals.Set of estrogen-responsive genes has been identified that can serve as a biomarker of environmental exposure to xenoestrogens._Key Words:_ estrogen; toxicogenomics; transcription profile; dehydroepiandrosterone; tamoxifen; genomics.
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