Over c pass the 2nd way out beneath 'Security' in the tree ( admit active fulfilled to period in files on myputer. joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage joining Coverage > > > Medical News: Prescriptions Modafinil (Provigil) desire take Hypersensitivity retaliation ad degradation By Peggy Peck, manager copy editor MedPage Today Published: October 25, 2007 ROCKVILLE, Md.25 The FDA said Cephalon has agreed to update the modafinil (Provigil) appellation toprehend a threat about increased jeopardy of Stevens-Johnson syndrome and other dour rashes and hypersensitivity reactions.In a to physicians, Jeffrey M.M.President on medical services of Cephalon, warned that worldwide employment marketing revealed rare cases of dour orminatory adventurous including SJS, toxic epidermal necrolysis, and sedative adventurous with eosinophilia and systemic symptoms in adults and children.Multi- journal hypersensitivity reactions "including at least at a woman cataclysm in employment marketing exposure oblige occurred in close secular confederation to the induction of modafinil," he wrote.He said the sedative should be stopped at the primary make over of adventurous or other hypersensitivity resistance and patients should be advised to instantaneously tinkle their physicians.Dr.Also reminded clinicians that modafinil "is not approved on pediatric patients on any indication" and that the sedative can cause psychiatric symptoms including dreadpulsion hallucinations, and suicidal ideation.In clinical trials in pediatric patients, the sort of adventurous resulting in discontinuation of the sedative was upon 0.Per 1,585), a rate that included at a woman confirmed of SJS and at a woman of apparent multi- journal hypersensitivity resistance Also in the trials were several reported cases of fever along with vomiting and leukopenia.No dour rashes were reported in clinical trials of adults (0 per 4,264), according to Dr. Angioedema has also been reported in patients delightful modafinil, and Dr.Said patients should be advised to instantaneously lay off the drug if they exposure bump of thee eyes, lips, mistake or larynx and/or straits in swallowing, breathing, or hoarseness.Modafinil is a fretful arrangement prompt that is adapted to for treatment of saw wood disorders such as narcolepsy and movement stint sleep befuddle It is also adapted to along with uninterrupted despotic airway (CPAP) devices to touch on obstructive saw wood apnea-hypopnea syndrome.Total Your Knowledge(tm) aid your own thoughts, exposure questions, and knowledge to this scenario on the extras of all MedPage Today readers.Fee this Report This publicize helped me discontinue abreast of callow statistics and medical developments.Strongly Agree Strongly fall out This publicize improves my talent to oblige learned conversations with my patients.Strongly Agree Strongly fall out The in this publicize wishes relief me distinguish and treat patients effectively.
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