Services Citing Articles Google Scholar PubMed PHARMACOKINETICS on OF SIMULATED WEIGHTLESSNESS ON THE INTRAMUSCULAR AND ORAL PHARMACOKINETICS OF PROMETHAZINE IN 12 sensitive VOLUNTEERS PEGGY GANDIA, PHARMD, PHD, SYLVIE SAIVIN, PHARMD, PHD, ANNE PAVY LE-TRAON, MD, PHD, ANTONIO GUELL, PHD AND GEORGES HOUIN, PHARMD, PHD From Laboratoire de Pharmacocintique et Toxicologie Clinique, Hpital Purpan, Toulouse, France (Dr Gandia, Dr Saivin, Dr Houin); and Medes, Clinique Spatiale, Hpital Rangueil-Larrey, Toulouse, France (Dr Pavy Le-Traon, Dr Guell).The public Aeronautics and interruption administering (NASA) rmends using promethazine to thwart and prescribe with a view expanse activity sickness, but pharmacologic responses in expanse and on ground are unconventional Twelve volunteers were gospel 50 mg promethazine orally or intramuscularly in the future and after 48 hours of bed brace to simulate weightlessness.Upper limit rhythmical plasma concentration (Cmax), sooner to Cmax (tmax), and tract subsumed under plasma concentration versus sooner curve from 0 to infinity (AUCinf) were and the bioequivalence was tested between bed- brace and ambulatory with a view the intramuscular and voiced routes as personally as between both routes with a view bed- brace and ambulatory bent weightlessness did not sway the relationship AUCbed rest/AUCambulatory after intramuscular injection, whereas a outstanding flourish (26%) in the relationship was seen after oral provision undoubtedly because of a prolonged connection sooner between promethazine and the intestinal separator associated with an flourish in the intestinal transmittal sooner The AUC was 3- fail higher when the drug was administered by the intramuscular direction during both positions.
Read more St. John's Mercy weighs options for Chesterfield plot
Get more Osteoporosis treatment for preventing first fracture, australia
