Published October 17, 2007; doi:10. 0022-3077/07 $8.All Versions of this Article: 98/6/3143 _most recent_ Services Google Scholar PubMed HISTAMINE-INDUCED EXCITATORY RESPONSES IN MOUSE VENTROMEDIAL HYPOTHALAMIC NEURONS: IONIC MECHANISMS AND ESTROGENIC REGULATION JIN ZHOU viagra substitute , ANNA W.NINO DEVIDZE, QIUYU ZHANG, LEE-MING KOW AND DONALD W.Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York Submitted 26 March 2007; accepted in final form 12 October 2007 Histamine is capable of modulating CNS arousal states by regulating neuronal excitability.The current study filling online prescription viagra , histamine best herbal viagra action in the ventromedial hypothalamus (VMH), its related ionic mechanisms, and its possible facilitation by estrogen were investigated using whole cell patch-clamp free viagra online recording in brain slices from ovariectomized female mice.Current clamp, a bath application of histamine (20 M) caused membrane depolarization, associated with an increased membrane resistance.Some cells, the depolarization was apanied by action potentials.Application also significantly reduced the latency of action potential evoked herbal viagra for woman by current steps.Was not affected by either tetrodotoxin or Cd2+.After blocking K+ channels with tetraethylammonium, 4-aminopyridine, and Cs+, depolarization was significantly decreased.Voltage clamp, histamine-induced depolarization was associated with an inward current.Current-voltage relationship revealed that this inward current reversed near _E_K.Histamine effect was mimicked by a histamine receptor cyber pharmacy viagra 1 (H1) agonist, but not a histamine receptor 2 (H2) agonist.Antagonist, but not H2 antagonist, abolished histamine responses.Ovariectomized mice were treated with estradiol benzoate (E2), histamine-induced depolarization was significantly enhanced with an increased percentage of cells showing action potential firing.Results suggest that histamine depolarized VMH neurons by attenuating a K+ leakage current and this effect was mediated by H1 receptor.Facilitated histamine-induced excitation of VMH neurons.Histamine effect may present a potential mechanism by which estrogens modulate the impact of generalized CNS arousal on a sexual arousal-related neuronal group.
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