PubMed Result A service of the and the Search natural viagra PubMedProteinNucleotideCoreNucleotideGSSESTStructureGenomeBooksCancerChromosomesConserved DomainsdbGaP3D DomainsGeneGenome ProjectGENSATGEO ProfilesGEO drug viagra DataSetsHomoloGeneJournalsMeSHNCBI Web SiteNLM CatalogOMIAOMIMPMCPopSetProbeProtein ClustersPubChem BioAssayPubChempoundPubChem SubstanceSNPTaxonomyToolKitUniGeneUniSTS for GO CLEAR , , , , .Clinical Pharmacotherapy, Hiroshima University, ikawak@hiroshima-u.Lafutidine, a histamine H(2)-receptor antagonist, inhibits gastric acid secretion during the daytime, however, the relationship between the plasma concentration and the drug response remains unclear viagra success story .Aim of this study was topare the pharmacokinetic and pharmacodynamic properties of lafutidine and famotidine blog comment viagra following postprandial oral administration.A lafutidine tablet (10 mg), famotidine tablet (20 mg), or water only (control) was administered, blood samples were taken and intragastric pH was measured.Plasma concentrations of lafutidine and famotidine were determined by HPLC, and the median intragastric pH values per 30 min were used as the degrees of gastric acid suppression.Were analyzed based on a onepartment pharmacokinetic model and a sigmoid E(max) pharmacodynamic model.Concentrations rapidly increased after administration; famotidine required some time to increase the plasma concentrations, requiring an absorption lag time in the pharmacokinetic model.The plasma concentration and DeltapH (the difference in intragastric pH by the drug vs.Lafutidine showed an anticlockwise hysteresis loop which indicated equilibration delay between the plasma concentration and effect site woman use viagra , requiring an effect sitepartment in the pharmacodynamic model; famotidine showed more parallel relationship.Results indicated that the pharmacokinetic and pharmacodynamic properties of lafutidine after postprandial oral administration were different from those of famotidine at least 4.
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