M Backes Cheryl joke picture viagra A Gibson Janelle F Ruisinger Patrick M Moriarty DOI: 10.412 (100 K) PRINT ISSN: 0277-0008 VOLUME: 27 ISSUE: 3 COVER DATE allowed comment html leave viagra : March 2007 PAGE(S): 412-424 KEY WORDS fibric acid derivatives, fibrates, gemfibrozil, fenofibrate online purchasing viagra , hypercholesterolemia, coronary heart disease, CHD.ABSTRACT TEXT The prominent use of fibric acid derivatives has lessened over the is there a female viagra where is it available years because of unimpressive results in major clinical trials, safety concerns, and the emergence viagra sales uk of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).Was widely used in the 1970s, but after publication of results from two major trials demonstrating only modest reduction woman use viagra s in the rate of coronary heart disease (CHD) and concerns regarding an increase in the frequency of gallstones and overall mortality, its use subsided dramatically.The introduction of gemfibrozil in the 1980s came a renewed interest in the class, which was also supported by the published results of the Helsinki Heart Study; however, despite a significant reduction in CHD events and a sound safety profile, overall mortality wasparable to that with placebo.In the 1990s, awareness of the fibrates was heightened with the availability of fenofibrate and the findings of another major trial using gemfibrozil, the Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial (VA-HIT), which demonstrated impressive results in reducing cardiovascular events.Further strengthen the VA-HIT results, numerous post hoc analyses were performed on the data of major trials of fibrate therapy among patients with mixed dyslipidemia, with similar findings.Data from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study were published, indicating mixed results.40 years after the introduction of the fibrates, practitioners are still contemplating the role of these agents in the treatment of CHD.James M.Pharm.1 , Cheryl A.Ph.2, Janelle F. 3, Patrick M. 4 AUTHOR(S) AFFILIATIONS 1Department of Pharmacy Practice, University generic soft tab viagra of Kansas School of Pharmacy, Lawrence, Kansas and the Lipid, Atherosclerosis, Metabolic and LDL-Apheresis Center, University of Kansas Medical Center, Kansas City, Kansas.Medicine, University of Kansas Medical Center, Kansas City, Kansas.Pharmacy Practice, University of Kansas School of Pharmacy, Lawrence, Kansas, University of Kansas Medical Center, Kansas City, Kansas.Metabolic and LDL-Apheresis Center, and the Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.Requests to James M.
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