IMAGAWA, K.M.N.T.T.SUZUKI, M.1 Doct enunciated Program of Sports drug GSCHS, University of Tsukuba, Tsukuba, Japan 2 bank on of Clinical and theoretical Hematology, Doctoral Program in Advanced Biomedical Applications, GSCHS, University of Tsukuba, Tsukuba, Japan 3 dispensation of robustness Sciences, bank on of Neurology, Tsukuba University of Technology, Tsukuba, Japan 4 The Tokyo unusual poison probing Laboratories II, Kowa, Co, Tokyo, Japan 5 Center fitted Tsukuba Advanced probing coalition University of Tsukuba, Tsukuba, Japan ABSTRACT Erythropoietin gene speech is stimulated by hypoxia-inducible influence 1 and reserved by GATA.Non-Standard thusly drugs that attenuate the action of GATA and/or potentiate the vim of HIF-1 may developing Epo moulding and hemoglobin concentration.Effects of such drugs on lifetime dispatch and the passive mechanisms by which they may utilize effects are unclear.Hep3B cells, we showed that K-11706 inhibits GATA binding motion but enhances HIF-1 binding motion the speech levels of GATA and HIF-1 protein were not changed by the into the bargain of K-11706.Investigated the effects of K-11706 on Epo and Hb concentrations, hematocrit and endurance dispatch of mice (plete of mice = 40).Was dissolved in polyethylene glycol and administered via enunciated tube feeding to mice fitted either five or eight days.Tolerance dispatch was assessed using a treadmill.From the quadriceps muscles of mice were stained with ATPase.Of 3 mg/kg K-11706 fitted five or eight days significantly increased erythropoietin concentrations, hemoglobin concentrations, hematocrit and lifetime dispatch but the diameters of choleric sections and ratios of exemplar I, IIA and IIB muscle fibers were not troubled explication WORDS transcription factors - erythropoietin - treadmill solid printed matter as (42 kb) (188 kb) Other issues: Year2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 Page1-89 (01)91-178 (02)181-270 (03)273-358 (04)361-447 (05)449-542 (06)545-630 (07)633-712 (08)717-803 (09)807-896 (10)899-984 (11)987-1076 (12) Service (c)Thieme- fasten is a rite of the and .
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