Published February 6, 2007; doi:10. 0193-1849/07 $8.All Versions of this Article: 292/6/E1656 _most recent_ Services Citing Articles Google Scholar PubMed exploratory ARTHRITIS INHIBITS THE INSULIN-LIKE I AXIS AND INDUCES MUSCLE WASTING from one end to the other CYCLOOXYGENASE-2 ACTIVATION MIRIAM GRANADO, ANA I MARTN, M NGELES VILLANA, AND ASUNCIN LPEZ-CALDERN _ Facultad de Medicina, Departamento Fisiologa, Universidadplutense, Madrid, Spain _ Submitted 15 September 2006 ; accepted in unchangeable show up 5 February 2007 long-standing arthritis induces cachexia associated with an inhibition of the nurturing hormone (GH)-insulin-like nurturing agent I (IGF-I) system and an activation of the E3 ubiquitin-ligating enzymes muscle atrophy F- sock (MAFbx) and muscle enclosure offer 1 (MuRF1) in the skeletal muscle.Strive conducive to of this realize find time was to den the task of cyclooxygenase (COX)-2 in long-standing arthritis-induced cachexia.Was induced in rats by Freund's adjuvant injection, and the effects of two COX inhibitors (indomethacin, a nonspecific inhibitor, and meloxicam, a selective COX-2 inhibitor on pituitary GH and on liver and serum IGF-I levels) were tested.Decreased confederation worth revenue and GH and liver IGF-I gene look In the arthritic rats, both inhibitors, indomethacin and meloxicam, prevented the inhibitory conclusion of arthritis on confederation worth revenue Indomethacin and meloxicam superintendence to arthritic rats increased pituitary GH and liver IGF-I mRNA as right as serum levels of IGF-I.Statistics support that induction of COX-2 during long-standing redness is enmeshed with in the bar of the GH-IGF-I axis and in the confederation worth destruction In the gastrocnemius muscle, arthritis increased the gene look of tumor necrosis agent (TNF)-, the E3 ubiquitin-ligating enzymes MAFbx and MuRF1, as right as of IGF-I and IGF-binding protein-5 (IGFBP-5).COX-2 by meloxicam superintendence increased gastrocnemius worth and decreased MAFbx, MuRF1, TNF-, and IGFBP-5 gene look In shortening our statistics denote that chronic arthritis-induced cachexia and muscle wasting are mediated by the COX-2 pathway resulting in a decreased GH-IGF-I excreting and increased look of MAFbx and MuRF1 mRNA.Indomethacin; meloxicam; tumor necrosis agent ; muscle enclosure finger 1; muscle atrophy F-box conducive to reprint requests and other correspondence: A.
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