June 28, 2007; doi:10. 0193-1857/07 $8.All Versions of this Article: 293/2/G510 _most recent_ Services Google Scholar PubMed LIVER AND BILIARY patch STIMULATION OF FECAL wealth EXCRETION AND THE DISPOSAL OF PROTOPORPHYRIN IN A MURINE ideal inpensation ERYTHROPOIETIC PROTOPORPHYRIA KARIN E.GOOIJERT, RICK HAVINGA, ALIDA R.ENGE E.VENEKAMP-HOOLSEMA, FOLKERT KUIPERS, AND HENKJAN J._ Pediatric Gastroenterology, segment of Pediatrics, Groningen University guild to save poison investigation University of Groningen and University Medical Center Groningen, Groningen, The Netherlands _ Submitted 28 February 2007 ; accepted in end ceremony 6 June 2007 Erythropoietic protoporphyria (EPP) is characterized by toxic collection of the hydrophobicpound protoporphyrin (PP).Mice are an beast shape for kind-hearted EPP.We force demonstrated that the collection of another hydrophobicpound, unconjugated bilirubin, could effectively be treated by stimulation of fecal well-heeled excretion.Whether stimulation of fecal well-heeled excretion enhanced the disposal of PP in _fch_/_fch_ mice.Mice were fed to save 8 wk with a peak fat aliment (16 wt% fat; control) or with the peak well-heeled aliment muddled with either a nonabsorbable well-heeled (sucrose polyester) or the intestinal lipase inhibitor orlistat.Effects of the treatments on fecal excretion of well-heeled and PP and on hepatic PP concentrations werepared with control diets.Well-heeled excretion in _fch_/_fch_ mice on a peak well-heeled aliment was higher than in mice on a ignoble well-heeled aliment (+149%, _P_ < 0.Sucrose polyesters and orlistat increased fecal well-heeled excretion identical more, up to sixfold of dial values.Regardless not anyone of the singular treatments gripped fecal PP excretion or hepatic PP concentration.Of _fch_/_fch_ mice with a peak well-heeled aliment a nonabsorbable well-heeled aliment or with orlistat increased the fecal excretion of well-heeled but did not extend fecal PP excretion or shrink hepatic PP concentration.Give out observations state that collection of PP is not amenable to stimulation of fecal well-heeled excretion.Mice; ferochelatase; nonabsorbable fat; sucrose polyesters discourse to save reprint requests and other correspondence: H.Verkade, nucleus to save Liver, Digestive and Metabolic Diseases, Pediatric Gastroenterology, Dept.Pediatrics, CMC IV, Rm.Univ.Groningen, PO punch 30.
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