Why this message is appearing and what you can do to make your experience on this site better.Select Journal or Resource JAMA & Archives Home JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology OtolaryngologyHead & Neck Surgery Pediatrics Harald J.Verhaar, MD, PhD; Hamid R.Pour, MD, PhD; Andr Aleman, PhD; Tycho M.W.MD; J.H.Bosch, MD, PhD; Diederick E.MD, PhD; Yvonne T.Schouw, PhD _JAMA. CONTEXT Serum testosterone levels decline significantly with aging.Supplementation to older men might beneficially affect the aging processes.OBJECTIVE To investigate the effect of testosterone supplementation on functional mobility, cognitive function, bone mineral density, bodyposition, plasma lipids, quality of life, and safety parameters in older men with low normal testosterone levels.DESIGN, SETTING, AND PARTICIPANTS Double-blind, randomized, placebo-controlled trial of 237 healthy men between the ages of 60 and 80 years with a testosterone level lower than 13.From January 2004 to April 2005 at a university medical center in the Netherlands.INTERVENTION Participants were randomly assigned to receive 80 mg of testosterone undecenoate or a matching placebo twice daily for 6 months.MAIN OUE MEASURES Functional mobility (Stanford Health Assessment Questionnaire, timed get up and go test, isometric handgrip strength, isometric leg extensor strength), cognitive function (8 different cognitive instruments), bone mineral density of the hip and lumbar spine (dual-energy x-ray absorptiometry scanning), bodyposition (total body dual-energy x-ray absorptiometry and abdominal ultrasound of fat mass), metabolic risk factors (fasting plasma lipids, glucose, and insulin), quality of life (Short-Form Health 36 Survey and the Questions on Life Satisfaction Modules), and safety parameters (serum prostate-specific antigen level, ultrasonographic prostate volume, International Prostate Symptom score, serum levels of creatinine, aspartate aminotransferase, alanine aminotransferase, -glutamyltransferase, hemoglobin, and hematocrit).RESULTS A total of 207 menpleted the study.The study, lean body mass increased and fat mass decreased in the testosterone grouppared with the placebo group but these factors were not apanied by an increase of functional mobility or muscle strength.Function and bone mineral density did not change.Sensitivity improved but high-density lipoprotein cholesterol decreased; by the end of the study, 47.The testosterone group vs 35.The placebo group had the metabolic syndrome (_P_ = .Measures were no different except for one hormone-related quality-of-life measure that improved.Negative effects on prostate safety were detected.CONCLUSION Testosterone supplementation during 6 months to older men with a low normal testosterone concentration did not affect functional status or cognition but increased lean body mass and had mixed metabolic effects.TRIAL REGISTRATION isrctn.AUTHOR AFFILIATIONS: Departments of Geriatric Medicine (Drs Emmelot-Vonk, Verhaar, and Nakhai Pour) and Urology (Drs Lock and Bosch), Julius Center for Health Sciences and Primary Care (Drs Emmelot-Vonk, Nakhai Pour, Grobbee, and van der Schouw), University Medical Center Utrecht, Utrecht, the Netherlands; and BCN Neuroimaging Center, University of Groningen, Groningen, the Netherlands (Dr Aleman).RELATED ARTICLE THIS WEEK IN _JAMA_ _JAMA.Read more Alprazolam(alprazolam) tablet, extended release [teva pharmaceuticals usa]
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