Published November 21, 2007; doi:10. 0363-6119/08 $8.All Versions of this Article: 294/2/R528 _most recent_ Services Google Scholar PubMed DEVELOPMENTAL PHYSIOLOGY AND PREGNANCY MATERNAL OBESITY AT CONCEPTION PROGRAMS OBESITY IN THE OFFSPRING KARTIK SHANKAR,1,2 AMANDA HARRELL,1 XIAOLI LIU,1 JANET M.J.AND THOMAS M._ 1Arkansas Children's Nutrition Center, Little Rock; and Departments of 2Pharmacology and Toxicology, 3Physiology and Biophysics, and 4Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas _ Submitted 6 May 2007 ; accepted in final form 19 November 2007 Risk of obesity in adult life is subject to programming during gestation.Examine whether in utero exposure to maternal obesity increases the risk of obesity in offspring, we developed an overfeeding-based model of maternal obesity in rats utilizing intragastric feeding of diets via total enteral nutrition.Diets to adult female rats at 220 kcal/kg3/4 per day (15% excess calories/day)pared with 187 kcal/kg3/4 per day for 3 wk caused substantial increase in body weight gain, adiposity, serum insulin, leptin, and insulin resistance.Or obese female rats were mated with ad libitum AIN-93G-fed male rats.To obesity was ensured to be limited only to the maternal in utero environment by cross-fostering pups to lean dams having ad libitum access to AIN-93G diets throughout lactation.Of pups, birth weight, and size were not affected by maternal obesity.Offspring from each group were weaned at postnatal day (PND)21 to either AIN-93G diets or high-fat diets (45% fat calories).Weights of offspring from obese dams did not differ from offspring of lean dams when fed AIN-93G diets through PND130.Read more Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin
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