2004 TO CITE THIS ARTICLE: A.I.Mianowska, J.A.E.W.Bodalski (2008) Insulin sensitivity in Type 1 diabetic children and adolescents doi:10.02357.Abstract ORIGINAL ARTICLE INSULIN SENSITIVITY IN TYPE 1 DIABETIC CHILDREN AND ADOLESCENTS A.Pietrzak, B.J.H.Keenan, E.W.And J.Department of Children's Diseases, Medical University of Lodz, Poland, Vascular Cell Biology, Joslin Diabetes Center, Boston, MA, USA and Department of Pediatric Allergology, Gastroenterology and Nutrition, Medical University of Lodz, Poland ABBREVIATIONS BMI, body mass index; DBP, diastolic blood pressure; HbA1c, glycated haemoglobin; HDL, high-density lipoprotein; lbm, lean body mass; LDL, low-density lipoprotein; SBP, systolic blood pressure; SDS, standard deviation score _Correspondence to_: Agnieszka Szadkowska, Department of Children's Diseases, Medical University of Lodz, Sporna 36/50, 91-738 d, Poland.Keywords adolescents, children, diabetes, insulin sensitivity, obesity Diabet.(2008) ABSTRACT Aim To estimate insulin sensitivity in Type 1 diabetic children and adolescents, and assess the relationship between insulin sensitivity and clinical markers of adiposity and parameters of the metabolic syndrome.Methods A total of 202 patients aged 8-18 years with Type 1 diabetes and disease duration 1.Participated.Sensitivity was estimated by glucose uptake during an euglycaemic-hyperinsulinaemic clamp and was calculated as the average amount of glucose (Mlbm = mg/kglbm/min) required to maintain euglycaemia.Pressure, glycated haemoglobin (HbA1c) and lipid concentrations were measured.The Mlbm value ranged from 4.25.(mean 9.Mg/kglbm/min).Was a significant relationship between M value and patients' age (_r_ = -0.< 0.Insulin sensitivity decreased significantly with the onset of puberty; hence, it was significantly lower in pubertal and post-pubertal adolescents.Significantly more insulin resistant than boys (9. 10.Mg/kglbm/min, _P_ = 0.Sensitivity correlated with body mass index (_r_ = -0.< 0.Circumference (_r_ = -0.< 0.Skin fold (_r_ = -0.= 0.Skin fold (_r_ = -0.= 0.Fat (_r_ = -0.= 0.There was a relationship between Mlbm value, cholesterol (_r_ = -0.= 0.Cholesterol (_r_ = 0.= 0.(_r_ = -0.= 0.= -0.< 0.Systolic blood pressure (_r_ = -0.= 0.Insulin resistance was related to HbA1c (_r_ = -0.= 0.Additionally, there was a correlation between Mlbm value and insulin dose.Conclusions Children and adolescents with Type 1 diabetes mellitus have a very wide range of insulin sensitivity, which is determined by sex, age, amount of adipose tissue and glycaemic control.THIS ARTICLE SEARCH InSynergyPubMed (MEDLINE)CrossRefBy keywordsadolescentschildrendiabetesinsulin sensitivityobesityBy authorA.PietrzakB.Bodalska-LipiskaH. Toporowska-KowalskaW.Read more Potential synergy activity of the novel ceragenin, csa-13, against clinical isolates of pseudomonas aeruginosa, including multidrug-resistant p. aeruginosa
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