You be experiencing forgotten your username or open sesame we can .Menu Saved Items дёж–‡(з®ЂдЅ") дёж–‡(з№Ѓй«") English Deutsch н•њкµм–ґ ж—Ґжњ¬иЄћ Franais Espaol Ш§Щ„Ш№Ш±ШЁЩЉШ© Р СѓСЃСЃРєРёР№ newspaper Article Paracetamol (acetaminophen) esters of some non-steroidal anti- rousing carboxylic acids as requited prodrugs with improved healthy forefinger Journal Publisher BirkhГ¤ alcohol Basel ISSN 0925-4692 (Print) 1568-5608 (Online) Issue Category Review DOI 10.Pages 143-157 responsible suited for Collection SpringerLink Date Saturday, August 11, 2007 REVIEW Paracetamol (acetaminophen) esters of some non-steroidal anti- rousing carboxylic acids as requited prodrugs with improved healthy forefinger T.Fadl1 and F.Omar1 (1) jurisdiction of Pharmaceutical sanative Chemistry, licence of chemists shop Assiut University, 71526 Assiut, Egypt RECEIVED: 7 January 1998 ACCEPTED: 19 January 1998 Abstract Paracetamol (acetaminophen) esters of some acidic NSAIDs were synthesized and evaluated as requited prodrug forms with the plan suited for of improving the healthy forefinger restraint of the gastrointestinal toxicity.Structures of the synthesized esters were confirmed by IR and 1H-NMR spectroscopy and their perfection was established by fundamental analyses and TLC.Lasting quality studies revealed that the synthesized ester prodrugs 4A-F are sufficiently chemically established in non-enzymatic simulated gastric fluid (hydrochloric acid buffer of pH 1.1/2 15-45 h)) and in phosphate buffer of pH 7.1/2 4-40 h).80% lenient plasma and 10% rat liver homogenate, the requited prodrugs were establish to be susceptible to enzymatic hydrolysis releasing the corresponding NSAID and paracetamol at less faster rates (_t_ 1/2 15-385 min and 1-140 min, respectively).Fitted log P values indicated that the prodrugs 4A-F are more lipophilic than the mother drugs.In-vivo experiments in rabbits showed higher plasma levels of ibuprofen after verbal supervision of its ester prodrug 4Bpared with those resulting from an interchangeable amount of the corresponding earthly omnium gatherum suggestive gain in latency of bore start in mice has been observed up to 4 h after po supervision of 0.Of the prodrugs,pared with the corresponding earthly mixtures.Observations and scanning electromicrographs of the desire showed that the prodrugs induced danged spoonful irritancy in the gastric mucosa of mice after verbal supervision suited for 4 days.Results suggest that the synthesized requited ester prodrugs were characterized by a outdo healthy forefinger than the mother drugs.Keywords paracetamol (acetaminophen) - NSAIDs - chemical and enzymatic lasting quality - ulcerogenicity - bore start latency - prodrugs References secured to subscribers.Detect doubt Builder minute patent Within all content Within this journal Within this dispute Export this article Export this article as RIS section section PDF The of this authenticate is 1,089 kilobytes.It may be a lengthier download, this is the most faithful online size В© Springer.
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