10.2008 This Article Services Google Scholar PubMed EPIDEMIOLOGY INSULIN, INSULIN-LIKE GROWTH FACTOR-I, ENDOGENOUS ESTRADIOL, AND RISK OF COLORECTAL CANCER IN POSTMENOPAUSAL WOMEN MARC J.DONALD R.HERBERT YU3, SYLVIA WASSERTHEIL-SMOLLER1, THOMAS E.JOANN E.BARBARA V.WYLIE-ROSETT1, GARNET L.GLORIA Y.HO1, ROBERT C.JIXIN LI2, XIAONAN XUE1, TIFFANY G.ROBERT D.AND HOWARD D.1 Albert Einstein College of Medicine, Bronx, New York; 2 Rutgers University, New Brunswick, New Jersey; 3 Yale University School of Medicine, New Haven, Connecticut; 4 Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; 5 MedStar Research Institute, Hyattsville, Maryland; and 6 Fred Hutchinson Cancer Research Center, Seattle, Washington REQUESTS FOR REPRINTS: Marc Gunter, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461.718-430-3089; E-mail: mgunter{at}a. Obesity is a risk factor for colorectal cancer, and hyperinsulinemia, amon condition in obese patients, may underlie this relationship.In addition to its metabolic effects, has promitotic and antiapoptotic activity that may be tumorigenic.Factor (IGF)-I, a related hormone, shares sequence homology with insulin, and has even stronger mitogenic effects.Prospective colorectal cancer studies directly measured fasting insulin, and none evaluated free IGF-I, or endogenous estradiol, a potential cofactor in postmenopausal women.Read more Suboxone (buprenophine/naloxone) launched in uk for maintenance treatment of opioid dependence
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