ARTICLE LINKS: EFFECTS OF ESTRADIOL AND RALOXIFENE ON ARTERIAL THROMBOSIS IN OVARIECTOMIZED MICE.ARTICLES Menopause.2008.Abu-Fanne, Rami MD 1; Brzezinski, Amnon MD 2; Golomb, Mordechai BSc 1; Grad, Etty MSc 1; Foldes, A.MD 3; Shufaro, Yoel MD 2; Varon, David MD 4; Brill, Alexander PhD 4; Lotan, Chaim MD 1; Danenberg, Haim D.1 _ ABSTRACT: Objective: The effects of estrogen and selective estrogen receptor modulators (eg, raloxifene) on arterial thrombosis are not well defined.Study assessed the manner and mechanism by which estrogen and raloxifene affect homeostatic pathways in ovariectomized mice after acute arterial injury.Mice (3 weeks old) underwent ovariectomy or sham operation.Days after surgery, mice were assigned to treatment with estradiol (5.Raloxifene (2.Or placebo (n = 10-12/group).Biological effects of both treatments were assessed by measurements of bone mass and the degree of uterine atrophy.4 months of therapy, carotid artery thrombosis was induced by photochemical injury, and the time to vascular occlusion was measured.Treatments increased bone mineral density (4.Reversal of macroscopic uterine atrophy was observed only in estrogen-treated mice.Mice had a shorter time to occlusionpared with sham-operated mice (70.7.103 +/- 11.Accelerated thrombosis.Estradiol and raloxifene significantly inhibited intra-arterial thrombosis in ovariectomized mice, prolonging the time to occlusion to 136.13.141.Min, respectively.Levels in the lung tissue were significantly increased by both raloxifene and estradiol with endothelial nitric oxide synthase expression being unaltered.(measured by surface coverage under a shear rate of 1,800 s-1 for 2 min) was significantly reduced in ovariectomized animals, being 4.1.+/- 1.10.1.Raloxifene, estradiol, and placebo, respectively.Amplifies thrombosis.Found that 4 months of treatment with both estradiol and raloxifene attenuates intravascular thrombosis.Antithrombotic effect was apanied by increased expression of cyclooxygenase-2 and suppression of platelet surface adhesion.American Menopause Society Copyright 2008, The North American Menopause Society.Rights reserved.By Lippincott Williams & Wilkins.Read more Bisoprolol: acute generalised exanthematous pustulosis (first report) in an elderly patient: case report
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