1600-079X. Abstract NOVEL PATHWAY FOR _N_1-ACETYL-5-METHOXYKYNURAMINE: UVB-INDUCED LIBERATION OF CARBON MONOXIDE FROM PRECURSOR _N_ 1-ACETYL-_N_ 2-FORMYL-5-METHOXYKYNURAMINE Katinka Seever and Rdiger Hardeland Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Gttingen, Gttingen, Germany Address reprint requests to Rdiger Hardeland, Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Berliner Str.D-37073 Gttingen, Germany.ABSTRACT Abstract: Irradiation of the melatonin metabolite _N_1-acetyl-_N_2-formyl-5-methoxykynuramine (AFMK) with UV light of 254 nm causes the release of carbon monoxide (CO) and, thus, deformylation to _N_1-acetyl-5-methoxykynuramine (AMK).Of CO was demonstrated by reduction of PdCl2 to metallic palladium, under avoidance of actions by other reductants.AMK formation was not due to UV-induced hydroxyl radicals, because the reaction also took place with high efficiency in ethanol and 2-propanol.AMK was generated from AFMK by UVB on a dry thin layer chromatographic plate.AMK seems to be the major primary product generated by UVB radiation, prolonged exposure of AFMK led to various other products, especially formed by destruction of AMK, as shown by irradiation of this latterpound.Read more New azetidinone cholesterol absorption inhibitors
Get more The breast cancer continuum in hormone-receptor positive breast cancer in postmenopausal women: evolving management options focusing on aromatase inhibitors
