Also:_ REFERENCE The new research builds on previous randomized trials, including more than 2,700 patients, which reached the "startling" conclusion that IIT reduces the risk of death in critically ill patients, according to lead author Dr.Schetz of University of Leuven, Belgium.Those studies, one group of patients received IIT, with insulin given continuously to maintain normal glucose levels.Other group received conventional insulin therapy, in which blood glucose levels are allowed to rise above normal.Schetz and colleagues re-analyzed the trial data, focusing on differences in the rates of acute kidney injury (AKI) between the two treatment groups.Kidney injury is amon and seriousplication among patients admitted to the intensive care unit (ICU).Occurs in five to 30 percent of patients, with death rates exceeding 40 percent.Showed that AKI developed in 4.Of patients assigned to IIT,pared to 7.Of those receiving conventional insulin therapy.Reduction in AKI was greatest when glucose levels remained within the normal range.Intensive insulin therapy was more effective in protecting against AKI in patients admitted to the ICU after surgery (surgical ICU),pared to critically ill patients who did not undergo surgery (medical ICU).Can be explained by the fact that IIT is a preventive strategy that cannot heal damage that is already present," explains Dr."The medical ICU patients were much sicker to begin with and may have already had kidney damage.For many years, the medicalmunity has considered high blood sugar levels in critically ill patientscalled "stress diabetes"as a beneficial reaction of the body to ensure adequate energy supply to the organs during severe illness.New research grew out of studies led by Dr.Van den Berghe, exploring the hormonal changes induced by critical illness.Trials found that strict glucose control with IIT reduced the risk of death in both surgical and medical ICU patients.Of organ failure were also lower with IITpared to conventional insulin therapy.Van den Berghe is a co-author of the new study.The new analysis builds on these results by confirming that IIT reduces the risk of AKI in critically ill patients, especially after surgery.Finding is especially important, because intensive insulin therapy is the first medical treatment that has been clearly shown to protect the kidney of critically ill patients," Dr. More research is needed to clarify how IIT acts to protect the kidneyswhether by preventing direct kidney damage caused by high blood sugar, or through indirect effects.Of the mechanism, Dr.Concludes, "Since AKI is associated with increased morbidity and mortality, the goal should be to prevent its development.Dr.Berghe via the Catholic University of Leuven received an unrestricted research grant from Novo Nordisk._Adapted from materials provided by _.Need to cite this story in your essay, paper, or report?One of the following formats: APA MLA RELATED STORIES (Sep.2006) Diabetes puts people at risk of developing critical illness and dying early, but obesity without diabetes does not.Study published today in the open access journal Critical Care reveals that .> (Jun.2007) A simple laboratory test to measure protein Ca natural anti-blood-clotting substance that also reflects the level of inflammation in the bodymay offer a useful new indicator of the severity of .> (Feb.2007) Changing how critically ill patients are treated with hydrocortisone could reduce hyperglycemia.Results of a randomized controlled clinical trial, published today in the journal Critical Care, .> (Dec.2003) A study in the December issue of Mayo Clinic Proceedings on blood-sugar levels in 1,826 intensive care unit patients showed that hyperglycemia (high blood-sugar levels) increased the patients .> (Dec.2007) Increasing numbers of critically ill patients develop fungal or yeast infections, which are associated with high mortality.Reviewpares treatments involving single-drug antifungal .> _Number of stories in archives: 44,032_ _Find with keyword(s):_ Enter a keyword or phrase to search ScienceDaily's archives for related news topics, the latest news stories, reference articles, science videos, images, and books.IN: Some diabetes patients who cannot live without insulin injections now have a new option: a transplant of islet cells, which produce insulin in the.._.From _ __ IN OTHER NEWS . __ _.From _ Get the latest science news with our free email newsletters, updated daily and weekly.View hourly updated newsfeeds in your RSS reader: FEEDBACK _.We want to hear from you!Tell us what you think of the new ScienceDaily we wee both positive and negativements.Read more Consumption of vegetables alters morning urinary 6-sulfatoxymelatonin concentration
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