понедельник, 25 февраля 2008 г.

Half of patients undergoing cerebrovascular stent placement do not respond well to clopidogrel

The importance of platelet inhibition in the prevention of in-stent thrombosis and re-stenosis, there is a great incentive to ensure that adequate antiplatelet effects are achieved in high-risk patients," said Dr.Prabhakaran, stroke neurologist at Rush University Medical Center.The study reviewed 76 patients who underwent cerebrovascular stent placement for various clinical indications, including wide-neck aneurysm and intracranial stenosis.Used the VerifyNow rapid platelet function assay-aspirin (RPFA-ASA) to calculate aspirin reaction units and the P2Y12 assay (VerifyNow) to calculate P2Y12 reaction units and percentage platelet inhibition immediately before the endovascular procedure.In the 71 patients on aspirin in whom ARU was measured, only three patients had a low response to aspirin.The 55 patients in whom percentage platelet inhibition was measured, 28 patients (50.Clopidogrel resistance.Researchers observed a significant association between older age (over the age of 55) and clopidogrel resistance and there was a strong effect of diabetes on platelet activity suggesting that these patients may require alternate approaches."Our study shows that using a point-of-care platelet function test in patients undergoing cerebrovascular stent placement is feasible and may be a valuable tool in the prevention of stent-relatedplications," said Prabhakaran.To the international normalized ratio used for warfarin, platelet function tests provide objective measurement of antiplatelet efficacy and help tailor therapy on an individual basis.These preliminary results, the researchers encourage further studies on ideal doses, timing, and duration of antiplatelet therapy for cerebrovascular stent placement.You like to for our weekly ?The end of each week we'll send you an email containing links to the most popular articles (by page impression) from your chosen categories that appeared on News-Medical.That week.Will NOT be bombarded with advertising and you CAN unsubscribe at any time.More information or click here to view our .News-Medical.The worthy medical information: .Health News Disease/Infection News Devices/Technology News Healthcare News Medical Conditions Medical Procedures Medical Patent News Medical Research News Men's Health News Medical Science News Miscellaneous News Pharmaceutical News Medical Studies/Trials Women's Health News < Jump to News-Medical.This medical news service in accordance with these .Please note that medical information found on this website is designed to support, not to replace the relationship between patient and physician/doctor and the medical advice they may provide.
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