ARTICLE LINKS: URINARY CORTISOL TO CORTISONE METABOLITES RATIO IN PREDNISONE-TREATED AND SPONTANEOUSLY HYPERTENSIVE PATIENTS.ORIGINAL PAPERS Journal of Hypertension.March 2008.Olivieri, Oliviero a; Pizzolo, Francesca a; Ravagnani, Viviana b; Moretti, Lorenzo a; Carletto, Antonio b; Faccini, Giovanni c; Pasini, Francesco d; Friso, Simonetta a; Corrocher, Roberto a _ ABSTRACT: Objective and methods: Prednisone and its active metabolite prednisolone, both substrates for 11-HSD2), may represent a pharmacological challenge for the enzyme.Aim of the present work was to define the possible role of abnormal cortisol/cortisone handling, as revealed by an urinary tetrahydrocortisol + allotetrahydrocortisol (THFs)/tetrahydrocortisone (THE) ratio between 1.3.Measuring urinary cortisol and cortisone metabolites in: normotensive individuals (n = 100) who received 7-8 mg/day of oral prednisone and were then followed for development of hypertension; essential hypertensive (EH) participants from primary care (n = 103); and EH hypertensive patients referred to the Hypertension Unit (n = 141).One-third (14 out of 47, 30%) of glucorticoid-treated patients who developed hypertension showed a THFs/THE ratio >1.Seen in 3% (n = 3) and 14% (n = 19) of primary and tertiary care hypertensive patients, respectively.THFs/THE ratio >1.Associated with a 3.Risk of hypertension after glucocorticoid therapy, regardless of duration and intensity of prednisone therapy.Number of EH patients and glucocorticoid-treated participants shared a similar phenotype, characterized by both arterial hypertension and elevated urinary THFs/THE ratio.A phenotype is moremon in severely, rather than in mildly, hypertensive patients.Lippincott Williams & Wilkins, Inc.Copyright 2008, Lippincott Williams & Wilkins.Rights reserved.By Lippincott Williams & Wilkins.Read more Paracetamol (acetaminophen) esters of some non-steroidal anti-inflammatory carboxylic acids as mutual prodrugs with improved therapeutic index
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