четверг, 10 января 2008 г.

Novel quinazoline-based compounds impair prostate tumorigenesis by targeting tumor vascularity

10.(c) 2007 This Article Services Google Scholar PubMed EXPERIMENTAL THERAPEUTICS, MOLECULAR TARGETS, AND CHEMICAL BIOLOGY NOVEL QUINAZOLINE-BASEDPOUNDS IMPAIR PROSTATE TUMORIGENESIS BY TARGETING TUMOR VASCULARITY JASON B.YENG-JENG SHAW3, CHING-SHIH CHEN3 AND NATASHA KYPRIANOU1,2 1 Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine; 2 Division of Urology, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky; and 3 Division of Medicinal Chemistry and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio REQUESTS FOR REPRINTS: Natasha Kyprianou,bs Cancer Research download joke viagra buy.18.to link online viagra Building, Room 306, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536.859-323-9812; Fax: 859-323-1944; E-mail: nkypr2{at}uky.Previous evidence showed the ability of the quinazoline-based _1-adrenoreceptor antagonist doxazosin to suppress prostate tumor growth via apoptosis.This study, we carried out structural optimization of the chemical nucleus of doxazosin and a subsequent structure-function analysis toward the development of a novel viagra for woman class of apoptosis-inducing and angiogenesis-targeting agents.Leadpound, DZ-50, was effective at reducing endothelial cell viability via a nonapoptotic mechanism.With DZ-50 effectively prevented in vitro_ tube formation and _in vivo_ chorioallantoic membrane vessel development.Microscopy revealed a significantly reduced ability of tumor cells to attach to extracellular matrix and migrate through endothelial cells in the presence of DZ-50.Vivo_ tumorigenicty studies using two androgen-independent human prostate cancer xenografts viagra online bestellen , PC-3 and DU-145, showed that DZ-50 treatment leads to significant suppression of tumorigenic growth.To the drug at the time of tumor cell inoculation led to prevention of prostate cancer initiation.DZ-50 resulted in a reduced formation of prostate-tumor derived metastatic pfizer viagra lesions to the lungs in an _in vivo_ spontaneous metastasis assay.
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